Tonie Rocke
Tonie Rocke is a Research Epidemiologist at the National Wildlife Health Center.
Science and Products
Filter Total Items: 15
SPV field trials bait uptake data SPV field trials bait uptake data
These data were collected as part of a field trial to test the effectiveness of a sylvatic plague vaccine (see Rocke et al., 2017 for details). Vaccine and control plots were selected randomly from the available pairs at each location. Baits containing Rhodamine B, a biomarker, were distributed at each plot. At least 1 week and no more than 2 months post-baiting each year, local...
Monkeypox challenge of rope squirrels: data Monkeypox challenge of rope squirrels: data
Monkeypox virus (MPXV) is a zoonotic disease endemic in Central and West Africa and is the most virulent orthopoxvirus affecting humans since the eradication of variola virus (VARV). In order to assess their reservoir potential, wild-caught rope squirrels were experimentally infected via intranasal and intradermal exposure with a recombinant MPXV strain from Central Africa engineered to...
Field efficacy trials with sylvatic plague vaccine Field efficacy trials with sylvatic plague vaccine
These data were collected as part of a field trial to test the efficacy of a sylvatic plague vaccine. Treatment and control sites were selected randomly from the available sites at each location. Site pairs were a minimum of 20 acres, (with a few exceptions). Prairie dog trapping took place a minimum of two weeks post-baiting and trapping procedures were approved by the NWHC Animal Care...
Filter Total Items: 134
Plague and distemper: Threats to black-footed ferret conservation Plague and distemper: Threats to black-footed ferret conservation
No abstract available.
Authors
Tonie Rocke
Immunogenicity, safety, and anti-viral efficacy of a subunit SARS-CoV-2 vaccine candidate in captive black-footed ferrets (Mustela nigripes) and their susceptibility to viral challenge Immunogenicity, safety, and anti-viral efficacy of a subunit SARS-CoV-2 vaccine candidate in captive black-footed ferrets (Mustela nigripes) and their susceptibility to viral challenge
A preliminary vaccination trial against the emergent pathogen, SARS-CoV-2, was completed in captive black-footed ferrets (Mustela nigripes; BFF) to assess safety, immunogenicity, and anti-viral efficacy. Vaccination and boosting of 15 BFF with purified SARS-CoV-2 S1 subunit protein produced a nearly 150-fold increase in mean antibody titers compared to pre-vaccination titers. Serum...
Authors
Ariel Leon, Della Garelle, Airn Hartwig, Elizabeth Falendysz, Hon S. Ip, Julia Lankton, Tyler Tretten, Terry Spraker, Richard Bowen, Tonie Rocke
Potential effects of environmental conditions on prairie dog flea development and implications for sylvatic plague epizootics Potential effects of environmental conditions on prairie dog flea development and implications for sylvatic plague epizootics
Fleas are common ectoparasites of vertebrates worldwide and vectors of many pathogens causing disease, such as sylvatic plague in prairie dog colonies. Development of fleas is regulated by environmental conditions, especially temperature and relative humidity. Development rates are typically slower at low temperatures and faster at high temperatures, which are bounded by lower and upper...
Authors
Michael D. Samuel, Julia Poje, Tonie Rocke, Marco Metzger
Social effects of rabies infection in male vampire bats (Desmodus rotundus) Social effects of rabies infection in male vampire bats (Desmodus rotundus)
Rabies virus (RABV) transmitted by the common vampire bat (Desmodus rotundus) poses a threat to agricultural development and public health throughout the Neotropics. The ecology and evolution of rabies host-pathogen dynamics are influenced by two infection-induced behavioral changes. RABV-infected hosts often exhibit increased aggression which facilitates transmission, and rabies also...
Authors
Elsa M. Cárdenas-Canales, Sebastian Stockmaier, Eleanor Cronin, Tonie Rocke, Jorge E. Osorio, Gerald Carter
A recombinant rabies vaccine that prevents viral shedding in rabid common vampire bats (Desmodus rotundus) A recombinant rabies vaccine that prevents viral shedding in rabid common vampire bats (Desmodus rotundus)
Vampire bat transmitted rabies (VBR) is a continuing burden to public health and agricultural sectors in Latin America, despite decades-long efforts to control the disease by culling bat populations. Culling has been shown to disperse bats, leading to an increased spread of rabies. Thus, non-lethal strategies to control VBR, such as vaccination, are desired. Here, we evaluated the safety...
Authors
Elsa Cardenas-Canales, Andres Velasco-Villa, James Ellison, Panayampalli S. Satheshkumar, Jorge Osario, Tonie Rocke
Impact of molecular modifications on the Immunogenicity and efficacy of recombinant raccoon poxvirus-vectored rabies vaccine candidates in mice Impact of molecular modifications on the Immunogenicity and efficacy of recombinant raccoon poxvirus-vectored rabies vaccine candidates in mice
Rabies is an ancient disease that is responsible for approximately 59,000 human deaths annually. Bats (Order Chiroptera) are thought to be the original hosts of rabies virus (RABV) and currently account for most rabies cases in wildlife in the Americas. Vaccination is being used to manage rabies in other wildlife reservoirs like fox and raccoon, but no rabies vaccine is available for...
Authors
Carly Malave, Jaime Lopera-Madrid, Lex Medina-Magues, Tonie Rocke, Jorge E. Osorio
Enzootic plague reduces survival of Mexican woodrats (Neotoma mexicana) in Colorado Enzootic plague reduces survival of Mexican woodrats (Neotoma mexicana) in Colorado
Plague is a flea-vectored disease introduced to North America c. 1900. It is lethal to many American mammal species, causes major die-offs (epizootics) in some populations, and may be ecologically disruptive even at lower interepizootic (enzootic) levels of transmission. We sought to determine the effects of enzootic plague on survival of Mexican woodrats (Neotoma mexicana) and to test...
Authors
Dean Biggins, Shantini Ramakrishnan, Tonie Rocke, Judy Williamson, Jeffrey Wimsatt
Space matters: Host spatial structure and the dynamics of plague transmission Space matters: Host spatial structure and the dynamics of plague transmission
The development of models to elucidate the transmission pathways and dynamics of wildlife diseases remains challenging. Sylvatic plague, caused by the bacterium Yersinia pestis (Yp), is an infectious zoonotic disease that primarily affects wild rodents, including prairie dogs (Cynomys spp.) in North America. Proposed transmission pathways for Yp include flea bites, direct contacts...
Authors
Robin E. Russell, Daniel Walsh, Michael D. Samuel, Martin Grunnill, Tonie Rocke
Sentinel coyote pathogen survey to assess declining black-footed ferret (Mustela nigripes) population in South Dakota, USA Sentinel coyote pathogen survey to assess declining black-footed ferret (Mustela nigripes) population in South Dakota, USA
As part of the national recovery effort, endangered black-footed ferrets (Mustela nigripes) were reintroduced to the Cheyenne River Sioux Reservation in South Dakota, US in 2000. Despite an encouraging start, numbers of ferrets at the site have declined. In an effort to determine possible causes of the population decline, we undertook a pathogen survey in 2012 to detect exposure to West...
Authors
Krysten Schuler, Michael Claymore, Hannah Schnitzler, Edward Dubovi, Tonie Rocke, Michael Perry, Dwight Bowman, Rachel Abbott
Experimental challenge of a North American bat species, big brown bat (Eptesicus fuscus), with SARS-CoV-2 Experimental challenge of a North American bat species, big brown bat (Eptesicus fuscus), with SARS-CoV-2
The recently emerged novel coronavirus, SARS‐CoV‐2, is phylogenetically related to bat coronaviruses (CoVs), specifically SARS‐related CoVs from the Eurasian bat family Rhinolophidae. As this human pandemic virus has spread across the world, the potential impacts of SARS‐CoV‐2 on native North American bat populations are unknown, as is the ability of North American bats to serve as...
Authors
Jeffrey Hall, Susan Knowles, Sean Nashold, Hon S. Ip, Ariel Leon, Tonie Rocke, Saskia Keller, Mariano Carossino, Udeni Balasuriya, Erik Hofmeister
Characterizing patterns of genomic variation in the threatened Utah prairie dog: Implications for conservation and management Characterizing patterns of genomic variation in the threatened Utah prairie dog: Implications for conservation and management
Utah prairie dogs (Cynomys parvidens) are federally threatened due to eradication campaigns, habitat destruction, and outbreaks of plague. Today, Utah prairie dogs exist in small, isolated populations, making them less demographically stable and more susceptible to erosion of genetic variation by genetic drift. We characterized patterns of genetic structure at neutral and putatively...
Authors
Rachel Giglio, Tonie Rocke, Jorge E. Osorio, Emily Latch
Impacts of environmental conditions on fleas in black-tailed prairie dog burrows Impacts of environmental conditions on fleas in black-tailed prairie dog burrows
Sylvatic plague, caused by the bacterium Yersinia pestis and transmitted by fleas, occurs in prairie dogs of the western United States. Outbreaks can devastate prairie dog communities, often causing nearly 100% mortality. Three competent flea vectors, prairie dog specialists Oropsylla hirsuta and O. tuberculata, and generalist Pulex simulans, are found on prairie dogs and in their...
Authors
Julia Poje, Tonie Rocke, Michael D. Samuel
Science and Products
Filter Total Items: 15
SPV field trials bait uptake data SPV field trials bait uptake data
These data were collected as part of a field trial to test the effectiveness of a sylvatic plague vaccine (see Rocke et al., 2017 for details). Vaccine and control plots were selected randomly from the available pairs at each location. Baits containing Rhodamine B, a biomarker, were distributed at each plot. At least 1 week and no more than 2 months post-baiting each year, local...
Monkeypox challenge of rope squirrels: data Monkeypox challenge of rope squirrels: data
Monkeypox virus (MPXV) is a zoonotic disease endemic in Central and West Africa and is the most virulent orthopoxvirus affecting humans since the eradication of variola virus (VARV). In order to assess their reservoir potential, wild-caught rope squirrels were experimentally infected via intranasal and intradermal exposure with a recombinant MPXV strain from Central Africa engineered to...
Field efficacy trials with sylvatic plague vaccine Field efficacy trials with sylvatic plague vaccine
These data were collected as part of a field trial to test the efficacy of a sylvatic plague vaccine. Treatment and control sites were selected randomly from the available sites at each location. Site pairs were a minimum of 20 acres, (with a few exceptions). Prairie dog trapping took place a minimum of two weeks post-baiting and trapping procedures were approved by the NWHC Animal Care...
Filter Total Items: 134
Plague and distemper: Threats to black-footed ferret conservation Plague and distemper: Threats to black-footed ferret conservation
No abstract available.
Authors
Tonie Rocke
Immunogenicity, safety, and anti-viral efficacy of a subunit SARS-CoV-2 vaccine candidate in captive black-footed ferrets (Mustela nigripes) and their susceptibility to viral challenge Immunogenicity, safety, and anti-viral efficacy of a subunit SARS-CoV-2 vaccine candidate in captive black-footed ferrets (Mustela nigripes) and their susceptibility to viral challenge
A preliminary vaccination trial against the emergent pathogen, SARS-CoV-2, was completed in captive black-footed ferrets (Mustela nigripes; BFF) to assess safety, immunogenicity, and anti-viral efficacy. Vaccination and boosting of 15 BFF with purified SARS-CoV-2 S1 subunit protein produced a nearly 150-fold increase in mean antibody titers compared to pre-vaccination titers. Serum...
Authors
Ariel Leon, Della Garelle, Airn Hartwig, Elizabeth Falendysz, Hon S. Ip, Julia Lankton, Tyler Tretten, Terry Spraker, Richard Bowen, Tonie Rocke
Potential effects of environmental conditions on prairie dog flea development and implications for sylvatic plague epizootics Potential effects of environmental conditions on prairie dog flea development and implications for sylvatic plague epizootics
Fleas are common ectoparasites of vertebrates worldwide and vectors of many pathogens causing disease, such as sylvatic plague in prairie dog colonies. Development of fleas is regulated by environmental conditions, especially temperature and relative humidity. Development rates are typically slower at low temperatures and faster at high temperatures, which are bounded by lower and upper...
Authors
Michael D. Samuel, Julia Poje, Tonie Rocke, Marco Metzger
Social effects of rabies infection in male vampire bats (Desmodus rotundus) Social effects of rabies infection in male vampire bats (Desmodus rotundus)
Rabies virus (RABV) transmitted by the common vampire bat (Desmodus rotundus) poses a threat to agricultural development and public health throughout the Neotropics. The ecology and evolution of rabies host-pathogen dynamics are influenced by two infection-induced behavioral changes. RABV-infected hosts often exhibit increased aggression which facilitates transmission, and rabies also...
Authors
Elsa M. Cárdenas-Canales, Sebastian Stockmaier, Eleanor Cronin, Tonie Rocke, Jorge E. Osorio, Gerald Carter
A recombinant rabies vaccine that prevents viral shedding in rabid common vampire bats (Desmodus rotundus) A recombinant rabies vaccine that prevents viral shedding in rabid common vampire bats (Desmodus rotundus)
Vampire bat transmitted rabies (VBR) is a continuing burden to public health and agricultural sectors in Latin America, despite decades-long efforts to control the disease by culling bat populations. Culling has been shown to disperse bats, leading to an increased spread of rabies. Thus, non-lethal strategies to control VBR, such as vaccination, are desired. Here, we evaluated the safety...
Authors
Elsa Cardenas-Canales, Andres Velasco-Villa, James Ellison, Panayampalli S. Satheshkumar, Jorge Osario, Tonie Rocke
Impact of molecular modifications on the Immunogenicity and efficacy of recombinant raccoon poxvirus-vectored rabies vaccine candidates in mice Impact of molecular modifications on the Immunogenicity and efficacy of recombinant raccoon poxvirus-vectored rabies vaccine candidates in mice
Rabies is an ancient disease that is responsible for approximately 59,000 human deaths annually. Bats (Order Chiroptera) are thought to be the original hosts of rabies virus (RABV) and currently account for most rabies cases in wildlife in the Americas. Vaccination is being used to manage rabies in other wildlife reservoirs like fox and raccoon, but no rabies vaccine is available for...
Authors
Carly Malave, Jaime Lopera-Madrid, Lex Medina-Magues, Tonie Rocke, Jorge E. Osorio
Enzootic plague reduces survival of Mexican woodrats (Neotoma mexicana) in Colorado Enzootic plague reduces survival of Mexican woodrats (Neotoma mexicana) in Colorado
Plague is a flea-vectored disease introduced to North America c. 1900. It is lethal to many American mammal species, causes major die-offs (epizootics) in some populations, and may be ecologically disruptive even at lower interepizootic (enzootic) levels of transmission. We sought to determine the effects of enzootic plague on survival of Mexican woodrats (Neotoma mexicana) and to test...
Authors
Dean Biggins, Shantini Ramakrishnan, Tonie Rocke, Judy Williamson, Jeffrey Wimsatt
Space matters: Host spatial structure and the dynamics of plague transmission Space matters: Host spatial structure and the dynamics of plague transmission
The development of models to elucidate the transmission pathways and dynamics of wildlife diseases remains challenging. Sylvatic plague, caused by the bacterium Yersinia pestis (Yp), is an infectious zoonotic disease that primarily affects wild rodents, including prairie dogs (Cynomys spp.) in North America. Proposed transmission pathways for Yp include flea bites, direct contacts...
Authors
Robin E. Russell, Daniel Walsh, Michael D. Samuel, Martin Grunnill, Tonie Rocke
Sentinel coyote pathogen survey to assess declining black-footed ferret (Mustela nigripes) population in South Dakota, USA Sentinel coyote pathogen survey to assess declining black-footed ferret (Mustela nigripes) population in South Dakota, USA
As part of the national recovery effort, endangered black-footed ferrets (Mustela nigripes) were reintroduced to the Cheyenne River Sioux Reservation in South Dakota, US in 2000. Despite an encouraging start, numbers of ferrets at the site have declined. In an effort to determine possible causes of the population decline, we undertook a pathogen survey in 2012 to detect exposure to West...
Authors
Krysten Schuler, Michael Claymore, Hannah Schnitzler, Edward Dubovi, Tonie Rocke, Michael Perry, Dwight Bowman, Rachel Abbott
Experimental challenge of a North American bat species, big brown bat (Eptesicus fuscus), with SARS-CoV-2 Experimental challenge of a North American bat species, big brown bat (Eptesicus fuscus), with SARS-CoV-2
The recently emerged novel coronavirus, SARS‐CoV‐2, is phylogenetically related to bat coronaviruses (CoVs), specifically SARS‐related CoVs from the Eurasian bat family Rhinolophidae. As this human pandemic virus has spread across the world, the potential impacts of SARS‐CoV‐2 on native North American bat populations are unknown, as is the ability of North American bats to serve as...
Authors
Jeffrey Hall, Susan Knowles, Sean Nashold, Hon S. Ip, Ariel Leon, Tonie Rocke, Saskia Keller, Mariano Carossino, Udeni Balasuriya, Erik Hofmeister
Characterizing patterns of genomic variation in the threatened Utah prairie dog: Implications for conservation and management Characterizing patterns of genomic variation in the threatened Utah prairie dog: Implications for conservation and management
Utah prairie dogs (Cynomys parvidens) are federally threatened due to eradication campaigns, habitat destruction, and outbreaks of plague. Today, Utah prairie dogs exist in small, isolated populations, making them less demographically stable and more susceptible to erosion of genetic variation by genetic drift. We characterized patterns of genetic structure at neutral and putatively...
Authors
Rachel Giglio, Tonie Rocke, Jorge E. Osorio, Emily Latch
Impacts of environmental conditions on fleas in black-tailed prairie dog burrows Impacts of environmental conditions on fleas in black-tailed prairie dog burrows
Sylvatic plague, caused by the bacterium Yersinia pestis and transmitted by fleas, occurs in prairie dogs of the western United States. Outbreaks can devastate prairie dog communities, often causing nearly 100% mortality. Three competent flea vectors, prairie dog specialists Oropsylla hirsuta and O. tuberculata, and generalist Pulex simulans, are found on prairie dogs and in their...
Authors
Julia Poje, Tonie Rocke, Michael D. Samuel