Tonie Rocke
Tonie Rocke is a Research Epidemiologist at the National Wildlife Health Center.
Science and Products
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Consumption of baits containing raccoon pox-based plague vaccines protects black-tailed prairie dogs (Cynomys ludovicianus) Consumption of baits containing raccoon pox-based plague vaccines protects black-tailed prairie dogs (Cynomys ludovicianus)
Baits containing recombinant raccoon poxvirus (RCN) expressing plague antigens (fraction 1 [F1] and a truncated form of the V protein-V307) were offered for voluntary consumption several times over the course of several months to a group of 16 black-tailed prairie dogs (Cynomys ludovicianus). For comparison, another group of prairie dogs (n = 12) was injected subcutaneously (SC) (prime...
Authors
Tonie Rocke, Nicola Pussini, Susan Smith, Judy Williamson, Bradford Powell, Jorge Osorio
Enzootic plague reduces black-footed ferret (Mustela nigripes) survival in Montana Enzootic plague reduces black-footed ferret (Mustela nigripes) survival in Montana
Black-footed ferrets (Mustela nigripes) require extensive prairie dog colonies (Cynomys spp.) to provide habitat and prey. Epizootic plague kills both prairie dogs and ferrets and is a major factor limiting recovery of the highly endangered ferret. In addition to epizootics, we hypothesized that enzootic plague, that is, presence of disease-causing Yersinia pestis without any noticeable...
Authors
Marc Matchett, Dean Biggins, Valerie Carlson, Bradford Powell, Tonie Rocke
Further development of raccoon poxvirus-vectored vaccines against plague (Yersinia pestis) Further development of raccoon poxvirus-vectored vaccines against plague (Yersinia pestis)
In previous studies, we demonstrated protection against plague in mice and prairie dogs using a raccoon pox (RCN) virus-vectored vaccine that expressed the F1 capsular antigen of Yersinia pestis. In order to improve vaccine efficacy, we have now constructed additional RCN-plague vaccines containing two different forms of the lcrV (V) gene, including full-length (Vfull) and a truncated...
Authors
Tonie Rocke, Keith Iams, S. Dawe, Susan Smith, Judy Williamson, Dennis Heisey, Jorge Osorio
Comparison of monkeypox viruses pathogenesis in mice by in vivo imaging Comparison of monkeypox viruses pathogenesis in mice by in vivo imaging
Monkeypox viruses (MPXV) cause human monkeypox, a zoonotic smallpox-like disease endemic to Africa, and are of worldwide public health and biodefense concern. Using viruses from the Congo (MPXV-2003-Congo-358) and West African (MPXV-2003-USA-044) clades, we constructed recombinant viruses that express the luciferase gene (MPXV-Congo/Luc+and MPXV-USA-Luc+) and compared their viral...
Authors
Jorge E. Osorio, Keith Iams, Carol Meteyer, Tonie Rocke
Attempts to identify Clostridium botulinum toxin in milk from three experimentally intoxicated Holstein cows Attempts to identify Clostridium botulinum toxin in milk from three experimentally intoxicated Holstein cows
Three adult lactating Holstein cows were injected in the subcutaneous abdominal vein with 175 ng/kg of body weight of Clostridium botulinum type C toxin (451 cow median toxic doses) to determine if this botulinum toxin crosses the blood–milk barrier. Whole blood (in sodium heparin) and clotted blood serum samples were taken at 0 min, 10 min, and 3, 6, 9, and 12 h postinoculation. Milk...
Authors
R.B. Moeller, B. Puschner, R.L. Walker, Tonie E. Rocke, S.R. Smith, J.S. Cullor, A.A. Ardans
Protecting Black-Footed Ferrets and Prairie Dogs against sylvatic plague Protecting Black-Footed Ferrets and Prairie Dogs against sylvatic plague
Scientists at the USGS National Wildlife Health Center (NWHC), in collaboration with colleagues at other federal agencies and the University of Wisconsin, are developing and testing vaccines that can be used to protect black-footed ferrets and prairie dogs against plague. The black-footed ferret is commonly regarded as the most endangered mammal in North America, and sylvatic plague is a...
Authors
Tonie Rocke
Exposure of mallards (Anas platyrhynchos) to the hepatotoxic cyanobacterium Nodularia spumigena Exposure of mallards (Anas platyrhynchos) to the hepatotoxic cyanobacterium Nodularia spumigena
Nodularin (NODLN) is a cyclic pentapeptide hepatotoxin produced by the cyanobacterium Nodularia spumigena, which forms extensive blooms during the summer in the Baltic Sea. Nodularin was detected in liver, muscle and/or feather samples of several common eiders (Somateria mollissima) from the Gulf of Finland (northern Baltic Sea) in 2002-2005. Published information on the adverse effects...
Authors
V.O. Sipia, J. Christian Franson, O. Sjovall, S. Pflugmacher, Valerie Shearn-Bochsler, Tonie Rocke, J.A.O. Meriluoto
Immunization of black-tailed prairie dog against plague through consumption of vaccine-laden baits Immunization of black-tailed prairie dog against plague through consumption of vaccine-laden baits
Prairie dogs (Cynomys spp.) are highly susceptible to Yersinia pestis and, along with other wild rodents, are significant reservoirs of plague for other wildlife and humans in the western United States. A recombinant raccoon poxvirus, expressing the F1 antigen of Y. pestis, was incorporated into a palatable bait and offered to three groups (n=18, 19, and 20) of black-tailed prairie dogs...
Authors
Tonie Rocke, Susan Smith, D.T. Stinchcomb, Jorge Osorio
Vaccination with F1-V fusion protein protects black-footed ferrets (Mustela nigripes) against plague upon oral challenge with Yersinia pestis Vaccination with F1-V fusion protein protects black-footed ferrets (Mustela nigripes) against plague upon oral challenge with Yersinia pestis
Previous studies have established that vaccination of black-footed ferrets (Mustela nigripes) with F1-V fusion protein by subcutaneous (SC) injection protects the animals against plague upon injection of the bacterium Yersinia pestis. This study demonstrates that the F1-V antigen can also protect ferrets against plague contracted via ingestion of a Y. pestis-infected mouse, a probable...
Authors
Tonie Rocke, Susan Smith, Paul E. Marinari, J. Kreeger, J.T. Enama, B.S. Powell
Prominent pancreatic endocrinopathy and altered control of food intake disrupt energy homeostasis in prion diseases Prominent pancreatic endocrinopathy and altered control of food intake disrupt energy homeostasis in prion diseases
Prion diseases are fatal neurodegenerative diseases that can induce endocrinopathies. The basis of altered endocrine function in prion diseases is not well understood, and the purpose of this study was to investigate the spatiotemporal relationship between energy homeostasis and prion infection in hamsters inoculated with either the 139H strain of scrapie agent, which induces preclinical...
Authors
J. Bailey, J.G. Berardinelli, Tonie E. Rocke, R. Bessen
An outbreak of type C botulism in Herring Gulls (Larus argentatus) in Southeastern Sweden An outbreak of type C botulism in Herring Gulls (Larus argentatus) in Southeastern Sweden
From 2000 to 2004, over 10,000 seabirds, primarily Herring Gulls (Larus argentatus), died from an undetermined cause in the Blekinge archipelago in southeastern Sweden. In June 2004, 24 affected Herring Gulls were examined clinically, killed humanely, and 23 were examined by necropsy. Seven and 10 unaffected Herring Gulls collected from a local landfill site and from Iceland...
Authors
A. Neimanis, D. Gavier-Widen, F. Leighton, T. Bollinger, Tonie Rocke, T. Morner
Avian botulism Avian botulism
This chapter contains section titled:IntroductionSynonymsHistoryDistributionHost RangeEtiologyEpizootiologyClinical SignsPathogenesisPathologyDiagnosisImmunityPublic Health ConcernsDomestic Animal Health ConcernsWildlife Population ImpactsTreatment and ControlLiterature Cited
Authors
Tonie Rocke, Trent K. Bollinger
Science and Products
Filter Total Items: 15
No Result Found
Filter Total Items: 134
Consumption of baits containing raccoon pox-based plague vaccines protects black-tailed prairie dogs (Cynomys ludovicianus) Consumption of baits containing raccoon pox-based plague vaccines protects black-tailed prairie dogs (Cynomys ludovicianus)
Baits containing recombinant raccoon poxvirus (RCN) expressing plague antigens (fraction 1 [F1] and a truncated form of the V protein-V307) were offered for voluntary consumption several times over the course of several months to a group of 16 black-tailed prairie dogs (Cynomys ludovicianus). For comparison, another group of prairie dogs (n = 12) was injected subcutaneously (SC) (prime...
Authors
Tonie Rocke, Nicola Pussini, Susan Smith, Judy Williamson, Bradford Powell, Jorge Osorio
Enzootic plague reduces black-footed ferret (Mustela nigripes) survival in Montana Enzootic plague reduces black-footed ferret (Mustela nigripes) survival in Montana
Black-footed ferrets (Mustela nigripes) require extensive prairie dog colonies (Cynomys spp.) to provide habitat and prey. Epizootic plague kills both prairie dogs and ferrets and is a major factor limiting recovery of the highly endangered ferret. In addition to epizootics, we hypothesized that enzootic plague, that is, presence of disease-causing Yersinia pestis without any noticeable...
Authors
Marc Matchett, Dean Biggins, Valerie Carlson, Bradford Powell, Tonie Rocke
Further development of raccoon poxvirus-vectored vaccines against plague (Yersinia pestis) Further development of raccoon poxvirus-vectored vaccines against plague (Yersinia pestis)
In previous studies, we demonstrated protection against plague in mice and prairie dogs using a raccoon pox (RCN) virus-vectored vaccine that expressed the F1 capsular antigen of Yersinia pestis. In order to improve vaccine efficacy, we have now constructed additional RCN-plague vaccines containing two different forms of the lcrV (V) gene, including full-length (Vfull) and a truncated...
Authors
Tonie Rocke, Keith Iams, S. Dawe, Susan Smith, Judy Williamson, Dennis Heisey, Jorge Osorio
Comparison of monkeypox viruses pathogenesis in mice by in vivo imaging Comparison of monkeypox viruses pathogenesis in mice by in vivo imaging
Monkeypox viruses (MPXV) cause human monkeypox, a zoonotic smallpox-like disease endemic to Africa, and are of worldwide public health and biodefense concern. Using viruses from the Congo (MPXV-2003-Congo-358) and West African (MPXV-2003-USA-044) clades, we constructed recombinant viruses that express the luciferase gene (MPXV-Congo/Luc+and MPXV-USA-Luc+) and compared their viral...
Authors
Jorge E. Osorio, Keith Iams, Carol Meteyer, Tonie Rocke
Attempts to identify Clostridium botulinum toxin in milk from three experimentally intoxicated Holstein cows Attempts to identify Clostridium botulinum toxin in milk from three experimentally intoxicated Holstein cows
Three adult lactating Holstein cows were injected in the subcutaneous abdominal vein with 175 ng/kg of body weight of Clostridium botulinum type C toxin (451 cow median toxic doses) to determine if this botulinum toxin crosses the blood–milk barrier. Whole blood (in sodium heparin) and clotted blood serum samples were taken at 0 min, 10 min, and 3, 6, 9, and 12 h postinoculation. Milk...
Authors
R.B. Moeller, B. Puschner, R.L. Walker, Tonie E. Rocke, S.R. Smith, J.S. Cullor, A.A. Ardans
Protecting Black-Footed Ferrets and Prairie Dogs against sylvatic plague Protecting Black-Footed Ferrets and Prairie Dogs against sylvatic plague
Scientists at the USGS National Wildlife Health Center (NWHC), in collaboration with colleagues at other federal agencies and the University of Wisconsin, are developing and testing vaccines that can be used to protect black-footed ferrets and prairie dogs against plague. The black-footed ferret is commonly regarded as the most endangered mammal in North America, and sylvatic plague is a...
Authors
Tonie Rocke
Exposure of mallards (Anas platyrhynchos) to the hepatotoxic cyanobacterium Nodularia spumigena Exposure of mallards (Anas platyrhynchos) to the hepatotoxic cyanobacterium Nodularia spumigena
Nodularin (NODLN) is a cyclic pentapeptide hepatotoxin produced by the cyanobacterium Nodularia spumigena, which forms extensive blooms during the summer in the Baltic Sea. Nodularin was detected in liver, muscle and/or feather samples of several common eiders (Somateria mollissima) from the Gulf of Finland (northern Baltic Sea) in 2002-2005. Published information on the adverse effects...
Authors
V.O. Sipia, J. Christian Franson, O. Sjovall, S. Pflugmacher, Valerie Shearn-Bochsler, Tonie Rocke, J.A.O. Meriluoto
Immunization of black-tailed prairie dog against plague through consumption of vaccine-laden baits Immunization of black-tailed prairie dog against plague through consumption of vaccine-laden baits
Prairie dogs (Cynomys spp.) are highly susceptible to Yersinia pestis and, along with other wild rodents, are significant reservoirs of plague for other wildlife and humans in the western United States. A recombinant raccoon poxvirus, expressing the F1 antigen of Y. pestis, was incorporated into a palatable bait and offered to three groups (n=18, 19, and 20) of black-tailed prairie dogs...
Authors
Tonie Rocke, Susan Smith, D.T. Stinchcomb, Jorge Osorio
Vaccination with F1-V fusion protein protects black-footed ferrets (Mustela nigripes) against plague upon oral challenge with Yersinia pestis Vaccination with F1-V fusion protein protects black-footed ferrets (Mustela nigripes) against plague upon oral challenge with Yersinia pestis
Previous studies have established that vaccination of black-footed ferrets (Mustela nigripes) with F1-V fusion protein by subcutaneous (SC) injection protects the animals against plague upon injection of the bacterium Yersinia pestis. This study demonstrates that the F1-V antigen can also protect ferrets against plague contracted via ingestion of a Y. pestis-infected mouse, a probable...
Authors
Tonie Rocke, Susan Smith, Paul E. Marinari, J. Kreeger, J.T. Enama, B.S. Powell
Prominent pancreatic endocrinopathy and altered control of food intake disrupt energy homeostasis in prion diseases Prominent pancreatic endocrinopathy and altered control of food intake disrupt energy homeostasis in prion diseases
Prion diseases are fatal neurodegenerative diseases that can induce endocrinopathies. The basis of altered endocrine function in prion diseases is not well understood, and the purpose of this study was to investigate the spatiotemporal relationship between energy homeostasis and prion infection in hamsters inoculated with either the 139H strain of scrapie agent, which induces preclinical...
Authors
J. Bailey, J.G. Berardinelli, Tonie E. Rocke, R. Bessen
An outbreak of type C botulism in Herring Gulls (Larus argentatus) in Southeastern Sweden An outbreak of type C botulism in Herring Gulls (Larus argentatus) in Southeastern Sweden
From 2000 to 2004, over 10,000 seabirds, primarily Herring Gulls (Larus argentatus), died from an undetermined cause in the Blekinge archipelago in southeastern Sweden. In June 2004, 24 affected Herring Gulls were examined clinically, killed humanely, and 23 were examined by necropsy. Seven and 10 unaffected Herring Gulls collected from a local landfill site and from Iceland...
Authors
A. Neimanis, D. Gavier-Widen, F. Leighton, T. Bollinger, Tonie Rocke, T. Morner
Avian botulism Avian botulism
This chapter contains section titled:IntroductionSynonymsHistoryDistributionHost RangeEtiologyEpizootiologyClinical SignsPathogenesisPathologyDiagnosisImmunityPublic Health ConcernsDomestic Animal Health ConcernsWildlife Population ImpactsTreatment and ControlLiterature Cited
Authors
Tonie Rocke, Trent K. Bollinger