Chronic wasting disease (CWD) affects cervids (elk, moose, mule deer, and white-tailed deer) throughout the U.S. CWD affects the nervous system in these animals and creates distinctive brain lesions. At this time, we have no treatment for CWD and it is fatal to the animals who contract it.
CWD is caused by an infectious, irregular form of cellular prion protein. CWD can be directly and indirectly transmitted through the contact with saliva, urine, feces, and infected carcasses, or CWD contaminated environmental surfaces.
USGS scientists are studying CWD to determine how the disease is transmitted, whether sex and/or age of the animal play a role in infection, and whether a genetic resistance is present in some animals.
CWD Research
Expanding Distribution of Chronic Wasting Disease
Modeling chronic wasting disease prevalence through time to investigate mechanisms of spread in deer and elk in Wyoming
Examining PRNP gene frequencies and ‘resistance’ to chronic wasting disease
Application of a systems approach for management of chronic wasting disease
Decision science support for Chronic Wasting Disease
Enhanced Capacity for Chronic Wasting Disease Research and Certified Diagnostics at the USGS National Wildlife Health Center
Assessing the Ability of Incineration to Inactivate CWD Prions from Carcasses
Advancing the Use of RT-QuIC for Applications in CWD Management
Chronic Wasting Disease
Effects of population density on prevalence of chronic wasting disease, physical condition, and vital rates of elk at Wind Cave National Park, South Dakota
Explore our science through the data below.
Supporting data: Spatial network clustering reveals elk population structure and local variation in prevalence of chronic wasting disease at Wind Cave National Park, 2005--18
Soil sample locations for chronic wasting disease prion surveillance in Grand Teton National Park and National Elk Refuge 2019
Soil sample locations for chronic wasting disease prion surveillance in Grand Teton National Park and National Elk Refuge 2019
Bighorn sheep Ovine HD array genotypes from National Parks, 2004-2011
Recent publications (2020-2022) related to USGS wild hoofstock disease research are listed below. A complete listing of USGS chronic wasting disease (CWD) publications is available from the button below. To find additional publications related to bighorn sheep, search bighorn sheep pneumonia in the search box in the blue navigation bar at the top of the page.
Using transcriptomics to predict and visualize disease status in bighorn sheep (Ovis canadensis)
Epidemiological differences between sexes affect management efficacy in simulated chronic wasting disease systems
Examination of the interaction between age-specific predation and chronic disease in the Greater Yellowstone Ecosystem
Disease and secondary sexual traits: Effects of pneumonia on horn size of bighorn sheep
Spatial network clustering reveals elk population structure and local variation in prevalence of chronic wasting disease
Natural history of a bighorn sheep pneumonia epizootic: Source of infection, course of disease, and pathogen clearance
Cognitive and behavioral coping in response to wildlife disease: The case of hunters and chronic wasting disease
Genomic association with pathogen carriage in bighorn sheep (Ovis canadensis)
A replication of proximity to chronic wasting disease, perceived risk, and social trust in managing agency between hunters in Minnesota and Illinois
Addressing disease risk to develop a health program for bighorn sheep in Montana
Gene transcript profiling in desert bighorn sheep
Removal of chronic Mycoplasma ovipneumoniae carrier ewes eliminates pneumonia in a bighorn sheep population
- Overview
Chronic wasting disease (CWD) affects cervids (elk, moose, mule deer, and white-tailed deer) throughout the U.S. CWD affects the nervous system in these animals and creates distinctive brain lesions. At this time, we have no treatment for CWD and it is fatal to the animals who contract it.
CWD is caused by an infectious, irregular form of cellular prion protein. CWD can be directly and indirectly transmitted through the contact with saliva, urine, feces, and infected carcasses, or CWD contaminated environmental surfaces.
USGS scientists are studying CWD to determine how the disease is transmitted, whether sex and/or age of the animal play a role in infection, and whether a genetic resistance is present in some animals.
CWD ResearchExpanding Distribution of Chronic Wasting Disease
Chronic wasting disease (CWD) has been detected in 31 US states and four Canadian provinces in free-ranging cervids and/or commercial captive cervid facilities. CWD has been detected in free-ranging cervids in 31 states and three provinces and in captive cervid facilities in 18 states and three provinces.Modeling chronic wasting disease prevalence through time to investigate mechanisms of spread in deer and elk in Wyoming
Diseases are challenging to manage in wild ungulate populations, particularly when there are many ways the disease can spread. Wildlife management agencies often need to take action to control disease spread, but it is unclear which actions are most effective in constraining disease because the importance of different spread mechanisms is not fully understood. This project will aid state wildlife...Examining PRNP gene frequencies and ‘resistance’ to chronic wasting disease
Multiple studies have demonstrated that various alleles of the cervid prion protein (PRNP) gene affect chronic wasting disease (CWD) progression.Application of a systems approach for management of chronic wasting disease
Managing chronic wasting disease (CWD) involves more than understanding the ecology of the disease. It includes complex relationships among social, economic, and political factors that affect intervention opportunities, consequences for stakeholders, and ultimately disease outcomes. The USGS National Wildlife Health Center, Montana Cooperative Wildlife Research Unit, Ventana Systems, Inc., and the...Decision science support for Chronic Wasting Disease
Eastern Ecological Science Center adds the decision analytical skill set to the existing body of USGS expertise on Chronic Wasting Disease (CWD), in support of our sister DOI agencies.Enhanced Capacity for Chronic Wasting Disease Research and Certified Diagnostics at the USGS National Wildlife Health Center
Chronic wasting disease (CWD) is a fatal disease that impacts populations of deer, elk, moose, and other cervid species caused by an infectious protein called a prion.Assessing the Ability of Incineration to Inactivate CWD Prions from Carcasses
Chronic wasting disease (CWD), a fatal neurologic disease of cervids, presents a monumental management challenge, in part because the etiological agent, an infectious prion, is extremely difficult to inactivate and can be transmitted directly or indirectly to hosts. Due to these attributes of prions, proper disposal of CWD-infected carcasses is an important consideration for management agencies to...Advancing the Use of RT-QuIC for Applications in CWD Management
Chronic wasting disease (CWD) is an emerging infectious disease that is fatal to free-ranging and captive animals in Cervidae, the deer family. The development of the real-time quaking-induced conversion (RT-QuIC) assay has the potential to transform laboratory research of prions and provide new opportunities for improved surveillance and management.Chronic Wasting Disease
Chronic wasting disease (CWD) is an emerging infectious disease that is fatal to free-ranging and captive animals in Cervidae, the deer family. CWD is one member of a family of diseases called transmissible spongiform encephalopathies (TSEs), and is thought to be caused by prions. CWD is the only TSE known to affect free-ranging wildlife.Effects of population density on prevalence of chronic wasting disease, physical condition, and vital rates of elk at Wind Cave National Park, South Dakota
CWD is a degenerative neurological disease caused by infectious proteins called prions. Although documented cases are invariably fatal, infected elk commonly survive for several months or longer, passing prions directly to other individuals and into the environment, where they bind to surfaces or soils and can persist for years. CWD reached Wind Cave National Park about 1997 and rapidly became the... - Data
Explore our science through the data below.
Supporting data: Spatial network clustering reveals elk population structure and local variation in prevalence of chronic wasting disease at Wind Cave National Park, 2005--18
These data were used for preparation of Sargeant et al. (2021), "Spatial network clustering reveals elk population structure and local variation in the prevalence of chronic wasting disease." They include locations of elk that were monitored with global positioning system collars at Wind Cave National Park, South Dakota (WICA) during 2005--08 and 2011--13; coordinates of a polygon describing the bSoil sample locations for chronic wasting disease prion surveillance in Grand Teton National Park and National Elk Refuge 2019
A total of 200 soil samples were collected in the Greater Yellowstone Ecosystem in Grand Teton National Park and the National Elk Refuge in July 2019 for chronic wasting disease (CWD) monitoring purposes. To collect samples from locations where ungulates are most likely to be shedding or encountering CWD, we targeted elk collar data locations, known migration routes of mule deer and elk, and areasSoil sample locations for chronic wasting disease prion surveillance in Grand Teton National Park and National Elk Refuge 2019
A total of 200 soil samples were collected in the Greater Yellowstone Ecosystem in Grand Teton National Park and the National Elk Refuge in July 2019 for chronic wasting disease (CWD) monitoring purposes. To collect samples from locations where ungulates are most likely to be shedding or encountering CWD, we targeted elk collar data locations, known migration routes of mule deer and elk, and areasBighorn sheep Ovine HD array genotypes from National Parks, 2004-2011
Between 2004 and 2011 bighorn sheep were darted in Glacier National Park and in Dinosaur National Monument. Blood was drawn. These are the genotypes resulting from an Ovine HD array from the bighorns. The first 3 columns refers to bighorn sheep identifiers: 'Herd_Unit', 'IndID', and 'AgencyID'. IndID is the identifier assigned at Montana State University. Subsequent columns each represent a locus, - Publications
Recent publications (2020-2022) related to USGS wild hoofstock disease research are listed below. A complete listing of USGS chronic wasting disease (CWD) publications is available from the button below. To find additional publications related to bighorn sheep, search bighorn sheep pneumonia in the search box in the blue navigation bar at the top of the page.
Using transcriptomics to predict and visualize disease status in bighorn sheep (Ovis canadensis)
Increasing risk of pathogen spillover coupled with overall declines in wildlife population abundance in the Anthropocene make infectious disease a relevant concern for species conservation worldwide. While emerging molecular tools could improve our diagnostic capabilities and give insight into mechanisms underlying wildlife disease risk, they have rarely been applied in practice. Here, employing aAuthorsLizabeth Bowen, Kezia R. Manlove, Annette Roug, Shannon C. Waters, Nate LaHue, Peregrine WolffEpidemiological differences between sexes affect management efficacy in simulated chronic wasting disease systems
Sex-based differences in physiology, behaviour and demography commonly result in differences in disease prevalence. However, sex differences in prevalence may reflect exposure rather than transmission, which could affect disease control programmes. One potential example is chronic wasting disease (CWD), which has been observed at greater prevalence among male than female deer.We used an age- and sAuthorsWilliam J. Rogers, Ellen E. Brandell, Paul C. CrossExamination of the interaction between age-specific predation and chronic disease in the Greater Yellowstone Ecosystem
Predators may create healthier prey populations by selectively removing diseased individuals. Predators typically prefer some ages of prey over others, which may, or may not, align with those prey ages that are most likely to be diseased.The interaction of age-specific infection and predation has not been previously explored and likely has sizable effects on disease dynamics. We hypothesize that pAuthorsEllen E. Brandell, Paul C. Cross, Douglas W. Smith, William J. Rogers, Nathan L. Galloway, Daniel R. MacNulty, Daniel R. Stahler, John J. Treanor, Peter J. HudsonDisease and secondary sexual traits: Effects of pneumonia on horn size of bighorn sheep
Secondary sexual traits (e.g., horns and antlers) have ecological and evolutionary importance and are of management interest for game species. Yet, how these traits respond to emerging threats like infectious disease remains underexplored. Infectious pneumonia threatens bighorn sheep (Ovis canadensis) populations across North America and we hypothesized it may also reduce horn growth in male sheepAuthorsAlynn Martin, John T. Hogg, Kezia R. Manlove, Tayler N LaSharr, Justin M. Shannon, Douglas E. McWhirter, Hollie Miyasaki, Kevin L. Monteith, Paul C. CrossSpatial network clustering reveals elk population structure and local variation in prevalence of chronic wasting disease
Spatial organization plays prominent roles in disease transmission, genetics, and demography of wildlife populations and is therefore an important consideration not only for wildlife management, but also for inference about populations and processes. We used hierarchical agglomerative clustering of a spatial graph network to partition Wind Cave National Park (WICA) into five regions used by 163 feAuthorsGlen A. Sargeant, Margaret A. Wild, Gregory M. Schroeder, Jenny G. Powers, Nathan L. GallowayNatural history of a bighorn sheep pneumonia epizootic: Source of infection, course of disease, and pathogen clearance
A respiratory disease epizootic at the National Bison Range (NBR) in Montana in 2016–2017 caused an 85% decline in the bighorn sheep population, documented by observations of its unmarked but individually identifiable members, the subjects of an ongoing long-term study. The index case was likely one of a small group of young bighorn sheep on a short-term exploratory foray in early summer of 2016.AuthorsT. E. Besser, E. Frances Cassirer, Amy Lisk, Danielle Nelson, Kezia R. Manlove, Paul C. Cross, John T. HoggCognitive and behavioral coping in response to wildlife disease: The case of hunters and chronic wasting disease
The transactional model of stress and coping (TMSC) provides a conceptual framework for understanding adaptations to stressors like chronic wasting disease (CWD). Understanding hunter response to stressors is important because decreased participation and satisfaction can affect individual well-being, cultural traditions, agency revenue, and local economies. Using TMSC, we explored how deer huntersAuthorsSusan A. Schroeder, Adam Landon, Louis J. Cornicelli, David C. Fulton, Leslie McInenlyGenomic association with pathogen carriage in bighorn sheep (Ovis canadensis)
Genetic composition can influence host susceptibility to, and transmission of, pathogens, with potential population‐level consequences. In bighorn sheep (Ovis canadensis), pneumonia epidemics caused by Mycoplasma ovipneumoniae have been associated with severe population declines and limited recovery across North America. Adult survivors either clear the infection or act as carriers that continuallAuthorsAlynn Martin, E. Frances Cassirer, Lisette P. Waits, Raina K. Plowright, Paul C. Cross, Kimberly R. AndrewsA replication of proximity to chronic wasting disease, perceived risk, and social trust in managing agency between hunters in Minnesota and Illinois
No abstract available.AuthorsKyle Smith, Susan A. Schroeder, Adam Landon, Louis J. Cornicelli, Leslie McInenly, David C. FultonAddressing disease risk to develop a health program for bighorn sheep in Montana
No abstract available.AuthorsSarah N. Sells, Michael S. Mitchell, Justin A. GudeGene transcript profiling in desert bighorn sheep
Respiratory disease is a key factor affecting the conservation and recovery of bighorn sheep (Ovis canadensis ) populations. Innovative, minimally invasive tools such as gene transcription–based diagnostics have the potential to improve our understanding of the broad range of factors that can affect the health of wild sheep. Evaluation of transcript levels for genes representative of multiple inteAuthorsLizabeth Bowen, Kathleen Longshore, Peregrine Wolff, Robert C. Klinger, Mike Cox, Sarah Bullock, Shannon C. Waters, A. Keith MilesRemoval of chronic Mycoplasma ovipneumoniae carrier ewes eliminates pneumonia in a bighorn sheep population
Chronic pathogen carriage is one mechanism that allows diseases to persist in populations. We hypothesized that persistent or recurrent pneumonia in bighorn sheep (Ovis canadensis ) populations may be caused by chronic carriers of Mycoplasma ovipneumoniae (Mo ). Our experimental approach allowed us to address a conservation need while investigating the role of chronic carriage in disease persistenAuthorsTyler Garwood, Chadwick P. Lehman, Daniel P. Walsh, E. Frances Cassirer, Thomas E. Besser, Jonathan A. Jenks