Gavin Saari, PhD
Gavin N. Saari
Professional Experience
(January 2022-present) Supervisory Research Toxicologist, U.S. GEOLOGICAL SURVEY Upper Midwest Environmental Sciences Center (La Crosse, Wisconsin, USA)
(July 2020-2022) Research Toxicologist, U.S. GEOLOGICAL SURVEY Upper Midwest Environmental Science Center Aquatic (La Crosse, Wisconsin, USA)
(Sept 2018- July 2020) Postdoctoral Fellow, UNIVERSITY of ALBERTA, Biological Sciences Department (Edmonton, Alberta, Canada)
(August 2012- December 2018) Doctoral Student- Research Assistant, BAYLOR UNIVERSITY (Waco, Texas, USA)
(June 2010- July 2012) Biologist, Student Contractor Services, U.S. ENVIRONMENTAL PROTECTION AGENCY (Duluth, Minnesota, USA)
(December 2007- June 2010) Student Laboratory Technician, UNIVERSITY OF WISCONSIN-SUPERIOR LAKE SUPERIOR RESEARCH INSTITUTE (Superior, Wisconsin, USA)
Education and Certifications
PhD- Environmental Science, BAYLOR UNIVERSITY (Waco, Texas, USA). December 2018. Department of Environmental Science.
B.S.- Biology, UNIVERSITY OF WISCONSIN-SUPERIOR (Superior, Wisconsin, USA), May 2010.
Science and Products
Determination of the Acute Toxicity of Model-based Candidate Chemical Toxicants to Native and Nonnative Fish Species in Static Exposures
Invasive fishes are of considerable concern to aquatic resource managers. For example, the common carp (Cyprinus carpio), originally brought over from Eurasia sometime in the 1800s are now ubiquitous in U.S. waters. Although they have been around for over 100 years and have become part of U.S. culture, they are still highly detrimental to aquatic ecosystems and a method to eradicate and control of...
Data release for determination of antimycin–a in liquid formulation by high performance liquid chromatography–mass spectrometry
Pesticide formulations containing the active ingredient Antimycin-A (ANT-A) have been used by fisheries and aquaculture managers for several decades to remove nuisance fish species. Analytical methods for measuring ANT-A during pesticide treatments have been reported using High Performance Liquid Chromatography (HPLC) paired with multiple detection methods (e.g., electrochemical, ultraviolet, fluo
Data release for toxicity of Antimycin A incorporated management bait for grass carp
The goal of this study was to develop and examine whether a management bait that can be used for selective control of grass carp. Our objectives were to 1) quantify the water-based 24-h LC50 of Antimycin-A for grass carp and rainbow trout, 2) quantify the 96-h LD50 of orally administered Antimycin-A laden bait for grass carp and rainbow trout, 3) quantify the leaching rate of Antimycin-A from the
Determination of antimycin–a in a liquid formulation by high performance liquid chromatography–mass spectrometry
Pesticide formulations containing the active ingredient antimycin–a (ANT–A) have been used by fisheries and aquaculture managers for several decades to remove nuisance fish species. Analytical methods for measuring ANT–A during pesticide treatments have been done using high performance liquid chromatography (HPLC) paired with multiple detection methods (for example, electrochemical, ultraviolet, f
Authors
Gavin N. Saari, J. Nolan Steiner, Bryan Lada, Nadia Carmosini
A novel tool to selectively deliver a control agent to filter-feeding silver and bighead carp
Invasive carp pose substantial economic and ecological damage when populations are widespread in freshwater systems within the United States. Resource managers in the United States have few chemical control tools to selectively remove nuisance fish. This study examined whether Antimycin–A (antimycin) wax encapsulated microparticles could cause selective lethality in invasive carps. The antimycin m
Authors
Blake W. Sauey, Gavin N. Saari, Joel G. Putnam, Justine E. Nelson, James J. Wamboldt, J. Nolan Steiner, Robin D. Calfee
Toxicity of a management bait for grass carp (Ctenopharyngodon idella) incorporated with Antimycin A
No current technology can specifically target grass carp (Ctenopharyngodon idella) for control within aquatic ecosystems. Rotenone and Carbon Dioxide-Carp are currently the only available registered pesticides for grass carp; they are nonselective and typically applied throughout the water, equally exposing target and native species. A more selective control tool or pesticide application could be
Authors
James J. Wamboldt, J. Nolan Steiner, Blake W. Sauey, Bryan Lada, Joel G. Putnam, Brianne Marjorie Korducki, Gavin N. Saari
Partitioning of chemicals in aquatic organisms
Human populations have utilized heavy metals and persistent organic pollutants for their physiochemical properties in industrial, agricultural, and consumer goods for decades. Limited knowledge on their persistence and toxicological effects has resulted in organisms being exposed to some of the most problematic compounds ever generated by humans. Although overlap in exposure paradigms exists for h
Authors
Gavin N. Saari, Samreen Siddiqui, Susanne M. Brander
Antimycin A species sensitivity distribution: Perspectives for non-indigenous fish control
The global transfer of aquatic biota outside their native geographical range has resulted in dramatic changes to biological communities. Many nonnative species introductions are facilitated by human activity and then spread intra-continentally through connected watersheds once established. Resource managers therefore utilize multiple control technologies, such as management chemicals, for fisherie
Authors
Gavin N. Saari
Emerging control strategies for integrated pest management of invasive carps
Invasive carps are ecologically and economically problematic fish species in many large river basins in the United States and pose a threat to aquatic ecosystems throughout much of North America. Four species of invasive carps: black carp (Mylopharyngodon piceus), grass carp (Ctenopharyngodon idella), silver carp (Hypophthalmichthys molitrix) and bighead carp (Hypophthalmichthys nobilis), are part
Authors
Aaron R. Cupp, Marybeth K. Brey, Robin D. Calfee, Duane Chapman, Richard A. Erickson, Jesse Robert Fischer, Andrea K. Fritts, Amy E. George, P. Ryan Jackson, Brent C. Knights, Gavin N. Saari, Patrick Kočovský
Non-USGS Publications**
Mielewczyk DA, Glover CN, Klaczek CE, Goss GG, Saari GN. (2023) Sub-chronic exposure to waterborne extracellular microcystin-LR impairs calcium homeostasis in rainbow trout. Ecotoxicology and Environmental Safety. 1;251:114542.
Glover CN, Klaczek CE, Goss GG, Saari GN. (2022) Factors affecting the binding of diltiazem to rainbow trout plasma: implications for the risk assessment of pharmaceuticals in aquatic systems. Environmental Toxicology and Chemistry. 41(12):3125-33.
Klaczek CE, Saari GN, Veilleux HD, Mielewczyk DA, Goss GG, Glover CN. (2022) Acute waterborne strontium exposure to rainbow trout: tissue accumulation, ionoregulatory effects, and the modifying influence of waterborne calcium. Aquatic Toxicology 1;245:106125.
Saari GN, Haddad SP, Mole RM, Hill BN, Steele WB, Lovin LM, Chambliss CK and Brooks BW. (2020) Low dissolved oxygen increases uptake of a model calcium channel blocker and alters its effects on adult Pimephales promelas. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 231:108719.
Hill BN, Saari GN, Steele WB, Corrales J and Brooks BW. (2020) Nutrients and salinity influence Prymnesium parvum (UTEX LB 2797) elicited sublethal toxicity in Pimephales promelas and Danio rerio. Harmful Algae 93:101795.
Steele WB, Kristofco LA, Corrales J, Saari GN, Corcoran EJ, Hill BN, Mills MG, Gallagher E, Kavanagh TJ, Melnikov F, Zimmerman JB, Voutchkova-Kostal AM (2019) Toward less hazardous industrial compounds: coupling quantum mechanical computations, biomarker responses, and behavioral profiles to identify bioactivity of Sn2 electrophiles in alternative vertebrate models. Chemical Research in Toxicology 33(2):367-380.
Scott WC, Haddad SP, Saari GN, Chambliss CK, Conkle JL, Matson CW, Brooks BW. (2019) Influence of salinity and pH on bioconcentration of ionizable pharmaceuticals by the gulf killifish, Fundulus grandis. Chemosphere 229:434-42.
Scott WC, Breed CS, Haddad SP, Burket SR, Saari GN, Pearce PJ, Chambliss CK, Brooks BW. (2019) Spatial and temporal influence of onsite wastewater treatment systems, centralized effluent discharge, and tides on aquatic hazards of nutrients, indicator bacteria, and pharmaceuticals in a coastal bayou. Science of the Total Environment 650:354-64.
Mills MG, Ramsden R, Ma EY, Corrales J, Kristofco LA, Steele WB, Saari GN, Melnikov F, Kostal J, Kavanagh TJ, Zimmerman JB, Voutchkova-Kostal AM, Brooks BW, Coish P, Anastas PT, Gallagher E (2019) CRISPR-generated Nrf2a loss-and gain-of-function mutants facilitate mechanistic analysis of chemical oxidative stress-mediated toxicity in zebrafish. Chemical Research in Toxicology 33(2):426-435.
Saari GN, Corrales J, Haddad S, Chambliss CK, Brooks BW. (2018) Influence of diltiazem on fathead minnows across dissolved oxygen gradients. Environmental Toxicology and Chemistry 37:2835-2850.
Haddad SP, Luek A, Scott WC, Saari GN, Burket SR, Kristofco LA, Corrales J, Rasmussen JB, Chambliss CK, Luers M, Rogers C, Brooks BW (2018) Spatio-temporal bioaccumulation and trophic transfer of ionizable pharmaceuticals in a semi-arid urban river influenced by snowmelt. Journal of hazardous materials 359:231-40
Steele WB, Kristofco LA, Corrales J, Saari GN, Haddad SP, Gallagher EP, Kavanagh TJ, Kostal J, Zimmerman JB, Voutchkova-Kostal A, Anastas P and Brooks BW (2018) Comparative behavioral toxicology of two common larval fish models: Exploring relationships among modes of action and locomotor responses. Science of the Total Environment 640:1587-1600.
Saari GN, Wang Z, Brooks BW. 2018. Revisiting inland hypoxia: Diverse exceedances of dissolved oxygen thresholds for freshwater aquatic life. Environmental Science and Pollution Research 25:3139–3150. DOI: 10.1007/s11356-017-8908-6
Coish P, Brooks BW, Gallagher EP, Mills M, Kavanagh TJ, Simcox N, Lasker GA, Botta D, Schmuck SC, Voutchkova-Kostal A, Kostal J, Mullins ML, Nesmith SN, Mellor KE, Corrales J, Kristofco L, Saari G, Steele WB, Shen LQ, Melnikov F, Zimmerman JB, Anastas PT. 2018. The Molecular Design Research Network. Toxicological Sciences 161: 241-248.
Mellor KE, Coish P, Brooks BW, Gallagher EP, Mills M, Kavanagh TJ, Simcox N, Lasker GA, Botta D, Schmuck SC, Voutchkova-Kostal A, Kostal J, Mullins ML, Nesmith SM, Corrales J, Kristofco L, Saari G, Steele WB, Melnikov F, Zimmerman JB, Anastas PT. 2018. The Safer Chemical Design Game. Gamification of green chemistry and safer chemical design concepts for high school and undergraduate students. Green Chemistry Letters and Reviews 11: 103-110.
Saari GN, Scott WC, Brooks BW. 2017. Global Scanning Assessment of Calcium Channel Blockers in the Environment: Review and Analysis of Occurrence, Ecotoxicology and Hazards in Aquatic Systems. Chemosphere 189: 466-478.
Corrales J, Kristofco LA, Steele WB, Saari GN, Kostal J, Williams ES, Mills M, Gallagher EP, Kavanagh TJ, Simcox N, Shen LQ, Melnikov F, Zimmerman JB, Voutchkova-Kostal AM, Anastas PT, and Brooks BW. 2017. Towards the design of less hazardous chemicals: Exploring comparative oxidative stress in two common animal models. Chemical Research in Toxicology 30: 893-904.
Haddad SP, Du B, Scott CS, Saari GN, Breed C, Kelly M, Broach L, Chambliss CK, Brooks BW. 2017. Ontogenetic dietary shifts and bioaccumulation of diphenhydramine in Mugil cephalus from an urban estuary. Marine Environmental Research 127: 155-162.
Scott WC, Du B, Haddad SP, Breed C, Saari GN, Kelly M, Broach L, Chambliss CK, Brooks BW. 2016. Spatiotemporal Influences on Emerging Water Quality Indicators: Predicted and Observed Therapeutic Dose Exceedances of Ionizable Pharmaceuticals in Fish Plasma from Urban Coastal Systems. Environmental Toxicology and Chemistry 35:983-995
Du B, Haddad SP, Luek A, Scott CS, Saari GN, Burket SR, Kelly M, Broach L, Rasmussen JB, Chambliss CK, Brooks BW. 2016. Bioaccumulation of ionizable pharmaceuticals in fish across habitats of a tidally-influenced urban bayou. Environmental Toxicology and Chemistry 35: 966-974.
Du B, Haddad SP, Luek A, Scott WC, Saari GN, Kristofco LA, Connors KA, Rash C, Rasmussen JB, Chambliss CK, Brooks B W. 2014. Bioaccumulation and trophic dilution of human pharmaceuticals across trophic positions of an effluent-dependent wadeable stream. Philosophical Transactions of the Royal Society B: Biological Sciences, 369(1656), 20140058.
Glover CN, Klaczek CE, Goss GG, Saari GN. (2022) Factors affecting the binding of diltiazem to rainbow trout plasma: implications for the risk assessment of pharmaceuticals in aquatic systems. Environmental Toxicology and Chemistry. 41(12):3125-33.
Klaczek CE, Saari GN, Veilleux HD, Mielewczyk DA, Goss GG, Glover CN. (2022) Acute waterborne strontium exposure to rainbow trout: tissue accumulation, ionoregulatory effects, and the modifying influence of waterborne calcium. Aquatic Toxicology 1;245:106125.
Saari GN, Haddad SP, Mole RM, Hill BN, Steele WB, Lovin LM, Chambliss CK and Brooks BW. (2020) Low dissolved oxygen increases uptake of a model calcium channel blocker and alters its effects on adult Pimephales promelas. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 231:108719.
Hill BN, Saari GN, Steele WB, Corrales J and Brooks BW. (2020) Nutrients and salinity influence Prymnesium parvum (UTEX LB 2797) elicited sublethal toxicity in Pimephales promelas and Danio rerio. Harmful Algae 93:101795.
Steele WB, Kristofco LA, Corrales J, Saari GN, Corcoran EJ, Hill BN, Mills MG, Gallagher E, Kavanagh TJ, Melnikov F, Zimmerman JB, Voutchkova-Kostal AM (2019) Toward less hazardous industrial compounds: coupling quantum mechanical computations, biomarker responses, and behavioral profiles to identify bioactivity of Sn2 electrophiles in alternative vertebrate models. Chemical Research in Toxicology 33(2):367-380.
Scott WC, Haddad SP, Saari GN, Chambliss CK, Conkle JL, Matson CW, Brooks BW. (2019) Influence of salinity and pH on bioconcentration of ionizable pharmaceuticals by the gulf killifish, Fundulus grandis. Chemosphere 229:434-42.
Scott WC, Breed CS, Haddad SP, Burket SR, Saari GN, Pearce PJ, Chambliss CK, Brooks BW. (2019) Spatial and temporal influence of onsite wastewater treatment systems, centralized effluent discharge, and tides on aquatic hazards of nutrients, indicator bacteria, and pharmaceuticals in a coastal bayou. Science of the Total Environment 650:354-64.
Mills MG, Ramsden R, Ma EY, Corrales J, Kristofco LA, Steele WB, Saari GN, Melnikov F, Kostal J, Kavanagh TJ, Zimmerman JB, Voutchkova-Kostal AM, Brooks BW, Coish P, Anastas PT, Gallagher E (2019) CRISPR-generated Nrf2a loss-and gain-of-function mutants facilitate mechanistic analysis of chemical oxidative stress-mediated toxicity in zebrafish. Chemical Research in Toxicology 33(2):426-435.
Saari GN, Corrales J, Haddad S, Chambliss CK, Brooks BW. (2018) Influence of diltiazem on fathead minnows across dissolved oxygen gradients. Environmental Toxicology and Chemistry 37:2835-2850.
Haddad SP, Luek A, Scott WC, Saari GN, Burket SR, Kristofco LA, Corrales J, Rasmussen JB, Chambliss CK, Luers M, Rogers C, Brooks BW (2018) Spatio-temporal bioaccumulation and trophic transfer of ionizable pharmaceuticals in a semi-arid urban river influenced by snowmelt. Journal of hazardous materials 359:231-40
Steele WB, Kristofco LA, Corrales J, Saari GN, Haddad SP, Gallagher EP, Kavanagh TJ, Kostal J, Zimmerman JB, Voutchkova-Kostal A, Anastas P and Brooks BW (2018) Comparative behavioral toxicology of two common larval fish models: Exploring relationships among modes of action and locomotor responses. Science of the Total Environment 640:1587-1600.
Saari GN, Wang Z, Brooks BW. 2018. Revisiting inland hypoxia: Diverse exceedances of dissolved oxygen thresholds for freshwater aquatic life. Environmental Science and Pollution Research 25:3139–3150. DOI: 10.1007/s11356-017-8908-6
Coish P, Brooks BW, Gallagher EP, Mills M, Kavanagh TJ, Simcox N, Lasker GA, Botta D, Schmuck SC, Voutchkova-Kostal A, Kostal J, Mullins ML, Nesmith SN, Mellor KE, Corrales J, Kristofco L, Saari G, Steele WB, Shen LQ, Melnikov F, Zimmerman JB, Anastas PT. 2018. The Molecular Design Research Network. Toxicological Sciences 161: 241-248.
Mellor KE, Coish P, Brooks BW, Gallagher EP, Mills M, Kavanagh TJ, Simcox N, Lasker GA, Botta D, Schmuck SC, Voutchkova-Kostal A, Kostal J, Mullins ML, Nesmith SM, Corrales J, Kristofco L, Saari G, Steele WB, Melnikov F, Zimmerman JB, Anastas PT. 2018. The Safer Chemical Design Game. Gamification of green chemistry and safer chemical design concepts for high school and undergraduate students. Green Chemistry Letters and Reviews 11: 103-110.
Saari GN, Scott WC, Brooks BW. 2017. Global Scanning Assessment of Calcium Channel Blockers in the Environment: Review and Analysis of Occurrence, Ecotoxicology and Hazards in Aquatic Systems. Chemosphere 189: 466-478.
Corrales J, Kristofco LA, Steele WB, Saari GN, Kostal J, Williams ES, Mills M, Gallagher EP, Kavanagh TJ, Simcox N, Shen LQ, Melnikov F, Zimmerman JB, Voutchkova-Kostal AM, Anastas PT, and Brooks BW. 2017. Towards the design of less hazardous chemicals: Exploring comparative oxidative stress in two common animal models. Chemical Research in Toxicology 30: 893-904.
Haddad SP, Du B, Scott CS, Saari GN, Breed C, Kelly M, Broach L, Chambliss CK, Brooks BW. 2017. Ontogenetic dietary shifts and bioaccumulation of diphenhydramine in Mugil cephalus from an urban estuary. Marine Environmental Research 127: 155-162.
Scott WC, Du B, Haddad SP, Breed C, Saari GN, Kelly M, Broach L, Chambliss CK, Brooks BW. 2016. Spatiotemporal Influences on Emerging Water Quality Indicators: Predicted and Observed Therapeutic Dose Exceedances of Ionizable Pharmaceuticals in Fish Plasma from Urban Coastal Systems. Environmental Toxicology and Chemistry 35:983-995
Du B, Haddad SP, Luek A, Scott CS, Saari GN, Burket SR, Kelly M, Broach L, Rasmussen JB, Chambliss CK, Brooks BW. 2016. Bioaccumulation of ionizable pharmaceuticals in fish across habitats of a tidally-influenced urban bayou. Environmental Toxicology and Chemistry 35: 966-974.
Du B, Haddad SP, Luek A, Scott WC, Saari GN, Kristofco LA, Connors KA, Rash C, Rasmussen JB, Chambliss CK, Brooks B W. 2014. Bioaccumulation and trophic dilution of human pharmaceuticals across trophic positions of an effluent-dependent wadeable stream. Philosophical Transactions of the Royal Society B: Biological Sciences, 369(1656), 20140058.
**Disclaimer: The views expressed in Non-USGS publications are those of the author and do not represent the views of the USGS, Department of the Interior, or the U.S. Government.
Science and Products
Determination of the Acute Toxicity of Model-based Candidate Chemical Toxicants to Native and Nonnative Fish Species in Static Exposures
Invasive fishes are of considerable concern to aquatic resource managers. For example, the common carp (Cyprinus carpio), originally brought over from Eurasia sometime in the 1800s are now ubiquitous in U.S. waters. Although they have been around for over 100 years and have become part of U.S. culture, they are still highly detrimental to aquatic ecosystems and a method to eradicate and control of...
Data release for determination of antimycin–a in liquid formulation by high performance liquid chromatography–mass spectrometry
Pesticide formulations containing the active ingredient Antimycin-A (ANT-A) have been used by fisheries and aquaculture managers for several decades to remove nuisance fish species. Analytical methods for measuring ANT-A during pesticide treatments have been reported using High Performance Liquid Chromatography (HPLC) paired with multiple detection methods (e.g., electrochemical, ultraviolet, fluo
Data release for toxicity of Antimycin A incorporated management bait for grass carp
The goal of this study was to develop and examine whether a management bait that can be used for selective control of grass carp. Our objectives were to 1) quantify the water-based 24-h LC50 of Antimycin-A for grass carp and rainbow trout, 2) quantify the 96-h LD50 of orally administered Antimycin-A laden bait for grass carp and rainbow trout, 3) quantify the leaching rate of Antimycin-A from the
Determination of antimycin–a in a liquid formulation by high performance liquid chromatography–mass spectrometry
Pesticide formulations containing the active ingredient antimycin–a (ANT–A) have been used by fisheries and aquaculture managers for several decades to remove nuisance fish species. Analytical methods for measuring ANT–A during pesticide treatments have been done using high performance liquid chromatography (HPLC) paired with multiple detection methods (for example, electrochemical, ultraviolet, f
Authors
Gavin N. Saari, J. Nolan Steiner, Bryan Lada, Nadia Carmosini
A novel tool to selectively deliver a control agent to filter-feeding silver and bighead carp
Invasive carp pose substantial economic and ecological damage when populations are widespread in freshwater systems within the United States. Resource managers in the United States have few chemical control tools to selectively remove nuisance fish. This study examined whether Antimycin–A (antimycin) wax encapsulated microparticles could cause selective lethality in invasive carps. The antimycin m
Authors
Blake W. Sauey, Gavin N. Saari, Joel G. Putnam, Justine E. Nelson, James J. Wamboldt, J. Nolan Steiner, Robin D. Calfee
Toxicity of a management bait for grass carp (Ctenopharyngodon idella) incorporated with Antimycin A
No current technology can specifically target grass carp (Ctenopharyngodon idella) for control within aquatic ecosystems. Rotenone and Carbon Dioxide-Carp are currently the only available registered pesticides for grass carp; they are nonselective and typically applied throughout the water, equally exposing target and native species. A more selective control tool or pesticide application could be
Authors
James J. Wamboldt, J. Nolan Steiner, Blake W. Sauey, Bryan Lada, Joel G. Putnam, Brianne Marjorie Korducki, Gavin N. Saari
Partitioning of chemicals in aquatic organisms
Human populations have utilized heavy metals and persistent organic pollutants for their physiochemical properties in industrial, agricultural, and consumer goods for decades. Limited knowledge on their persistence and toxicological effects has resulted in organisms being exposed to some of the most problematic compounds ever generated by humans. Although overlap in exposure paradigms exists for h
Authors
Gavin N. Saari, Samreen Siddiqui, Susanne M. Brander
Antimycin A species sensitivity distribution: Perspectives for non-indigenous fish control
The global transfer of aquatic biota outside their native geographical range has resulted in dramatic changes to biological communities. Many nonnative species introductions are facilitated by human activity and then spread intra-continentally through connected watersheds once established. Resource managers therefore utilize multiple control technologies, such as management chemicals, for fisherie
Authors
Gavin N. Saari
Emerging control strategies for integrated pest management of invasive carps
Invasive carps are ecologically and economically problematic fish species in many large river basins in the United States and pose a threat to aquatic ecosystems throughout much of North America. Four species of invasive carps: black carp (Mylopharyngodon piceus), grass carp (Ctenopharyngodon idella), silver carp (Hypophthalmichthys molitrix) and bighead carp (Hypophthalmichthys nobilis), are part
Authors
Aaron R. Cupp, Marybeth K. Brey, Robin D. Calfee, Duane Chapman, Richard A. Erickson, Jesse Robert Fischer, Andrea K. Fritts, Amy E. George, P. Ryan Jackson, Brent C. Knights, Gavin N. Saari, Patrick Kočovský
Non-USGS Publications**
Mielewczyk DA, Glover CN, Klaczek CE, Goss GG, Saari GN. (2023) Sub-chronic exposure to waterborne extracellular microcystin-LR impairs calcium homeostasis in rainbow trout. Ecotoxicology and Environmental Safety. 1;251:114542.
Glover CN, Klaczek CE, Goss GG, Saari GN. (2022) Factors affecting the binding of diltiazem to rainbow trout plasma: implications for the risk assessment of pharmaceuticals in aquatic systems. Environmental Toxicology and Chemistry. 41(12):3125-33.
Klaczek CE, Saari GN, Veilleux HD, Mielewczyk DA, Goss GG, Glover CN. (2022) Acute waterborne strontium exposure to rainbow trout: tissue accumulation, ionoregulatory effects, and the modifying influence of waterborne calcium. Aquatic Toxicology 1;245:106125.
Saari GN, Haddad SP, Mole RM, Hill BN, Steele WB, Lovin LM, Chambliss CK and Brooks BW. (2020) Low dissolved oxygen increases uptake of a model calcium channel blocker and alters its effects on adult Pimephales promelas. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 231:108719.
Hill BN, Saari GN, Steele WB, Corrales J and Brooks BW. (2020) Nutrients and salinity influence Prymnesium parvum (UTEX LB 2797) elicited sublethal toxicity in Pimephales promelas and Danio rerio. Harmful Algae 93:101795.
Steele WB, Kristofco LA, Corrales J, Saari GN, Corcoran EJ, Hill BN, Mills MG, Gallagher E, Kavanagh TJ, Melnikov F, Zimmerman JB, Voutchkova-Kostal AM (2019) Toward less hazardous industrial compounds: coupling quantum mechanical computations, biomarker responses, and behavioral profiles to identify bioactivity of Sn2 electrophiles in alternative vertebrate models. Chemical Research in Toxicology 33(2):367-380.
Scott WC, Haddad SP, Saari GN, Chambliss CK, Conkle JL, Matson CW, Brooks BW. (2019) Influence of salinity and pH on bioconcentration of ionizable pharmaceuticals by the gulf killifish, Fundulus grandis. Chemosphere 229:434-42.
Scott WC, Breed CS, Haddad SP, Burket SR, Saari GN, Pearce PJ, Chambliss CK, Brooks BW. (2019) Spatial and temporal influence of onsite wastewater treatment systems, centralized effluent discharge, and tides on aquatic hazards of nutrients, indicator bacteria, and pharmaceuticals in a coastal bayou. Science of the Total Environment 650:354-64.
Mills MG, Ramsden R, Ma EY, Corrales J, Kristofco LA, Steele WB, Saari GN, Melnikov F, Kostal J, Kavanagh TJ, Zimmerman JB, Voutchkova-Kostal AM, Brooks BW, Coish P, Anastas PT, Gallagher E (2019) CRISPR-generated Nrf2a loss-and gain-of-function mutants facilitate mechanistic analysis of chemical oxidative stress-mediated toxicity in zebrafish. Chemical Research in Toxicology 33(2):426-435.
Saari GN, Corrales J, Haddad S, Chambliss CK, Brooks BW. (2018) Influence of diltiazem on fathead minnows across dissolved oxygen gradients. Environmental Toxicology and Chemistry 37:2835-2850.
Haddad SP, Luek A, Scott WC, Saari GN, Burket SR, Kristofco LA, Corrales J, Rasmussen JB, Chambliss CK, Luers M, Rogers C, Brooks BW (2018) Spatio-temporal bioaccumulation and trophic transfer of ionizable pharmaceuticals in a semi-arid urban river influenced by snowmelt. Journal of hazardous materials 359:231-40
Steele WB, Kristofco LA, Corrales J, Saari GN, Haddad SP, Gallagher EP, Kavanagh TJ, Kostal J, Zimmerman JB, Voutchkova-Kostal A, Anastas P and Brooks BW (2018) Comparative behavioral toxicology of two common larval fish models: Exploring relationships among modes of action and locomotor responses. Science of the Total Environment 640:1587-1600.
Saari GN, Wang Z, Brooks BW. 2018. Revisiting inland hypoxia: Diverse exceedances of dissolved oxygen thresholds for freshwater aquatic life. Environmental Science and Pollution Research 25:3139–3150. DOI: 10.1007/s11356-017-8908-6
Coish P, Brooks BW, Gallagher EP, Mills M, Kavanagh TJ, Simcox N, Lasker GA, Botta D, Schmuck SC, Voutchkova-Kostal A, Kostal J, Mullins ML, Nesmith SN, Mellor KE, Corrales J, Kristofco L, Saari G, Steele WB, Shen LQ, Melnikov F, Zimmerman JB, Anastas PT. 2018. The Molecular Design Research Network. Toxicological Sciences 161: 241-248.
Mellor KE, Coish P, Brooks BW, Gallagher EP, Mills M, Kavanagh TJ, Simcox N, Lasker GA, Botta D, Schmuck SC, Voutchkova-Kostal A, Kostal J, Mullins ML, Nesmith SM, Corrales J, Kristofco L, Saari G, Steele WB, Melnikov F, Zimmerman JB, Anastas PT. 2018. The Safer Chemical Design Game. Gamification of green chemistry and safer chemical design concepts for high school and undergraduate students. Green Chemistry Letters and Reviews 11: 103-110.
Saari GN, Scott WC, Brooks BW. 2017. Global Scanning Assessment of Calcium Channel Blockers in the Environment: Review and Analysis of Occurrence, Ecotoxicology and Hazards in Aquatic Systems. Chemosphere 189: 466-478.
Corrales J, Kristofco LA, Steele WB, Saari GN, Kostal J, Williams ES, Mills M, Gallagher EP, Kavanagh TJ, Simcox N, Shen LQ, Melnikov F, Zimmerman JB, Voutchkova-Kostal AM, Anastas PT, and Brooks BW. 2017. Towards the design of less hazardous chemicals: Exploring comparative oxidative stress in two common animal models. Chemical Research in Toxicology 30: 893-904.
Haddad SP, Du B, Scott CS, Saari GN, Breed C, Kelly M, Broach L, Chambliss CK, Brooks BW. 2017. Ontogenetic dietary shifts and bioaccumulation of diphenhydramine in Mugil cephalus from an urban estuary. Marine Environmental Research 127: 155-162.
Scott WC, Du B, Haddad SP, Breed C, Saari GN, Kelly M, Broach L, Chambliss CK, Brooks BW. 2016. Spatiotemporal Influences on Emerging Water Quality Indicators: Predicted and Observed Therapeutic Dose Exceedances of Ionizable Pharmaceuticals in Fish Plasma from Urban Coastal Systems. Environmental Toxicology and Chemistry 35:983-995
Du B, Haddad SP, Luek A, Scott CS, Saari GN, Burket SR, Kelly M, Broach L, Rasmussen JB, Chambliss CK, Brooks BW. 2016. Bioaccumulation of ionizable pharmaceuticals in fish across habitats of a tidally-influenced urban bayou. Environmental Toxicology and Chemistry 35: 966-974.
Du B, Haddad SP, Luek A, Scott WC, Saari GN, Kristofco LA, Connors KA, Rash C, Rasmussen JB, Chambliss CK, Brooks B W. 2014. Bioaccumulation and trophic dilution of human pharmaceuticals across trophic positions of an effluent-dependent wadeable stream. Philosophical Transactions of the Royal Society B: Biological Sciences, 369(1656), 20140058.
Glover CN, Klaczek CE, Goss GG, Saari GN. (2022) Factors affecting the binding of diltiazem to rainbow trout plasma: implications for the risk assessment of pharmaceuticals in aquatic systems. Environmental Toxicology and Chemistry. 41(12):3125-33.
Klaczek CE, Saari GN, Veilleux HD, Mielewczyk DA, Goss GG, Glover CN. (2022) Acute waterborne strontium exposure to rainbow trout: tissue accumulation, ionoregulatory effects, and the modifying influence of waterborne calcium. Aquatic Toxicology 1;245:106125.
Saari GN, Haddad SP, Mole RM, Hill BN, Steele WB, Lovin LM, Chambliss CK and Brooks BW. (2020) Low dissolved oxygen increases uptake of a model calcium channel blocker and alters its effects on adult Pimephales promelas. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 231:108719.
Hill BN, Saari GN, Steele WB, Corrales J and Brooks BW. (2020) Nutrients and salinity influence Prymnesium parvum (UTEX LB 2797) elicited sublethal toxicity in Pimephales promelas and Danio rerio. Harmful Algae 93:101795.
Steele WB, Kristofco LA, Corrales J, Saari GN, Corcoran EJ, Hill BN, Mills MG, Gallagher E, Kavanagh TJ, Melnikov F, Zimmerman JB, Voutchkova-Kostal AM (2019) Toward less hazardous industrial compounds: coupling quantum mechanical computations, biomarker responses, and behavioral profiles to identify bioactivity of Sn2 electrophiles in alternative vertebrate models. Chemical Research in Toxicology 33(2):367-380.
Scott WC, Haddad SP, Saari GN, Chambliss CK, Conkle JL, Matson CW, Brooks BW. (2019) Influence of salinity and pH on bioconcentration of ionizable pharmaceuticals by the gulf killifish, Fundulus grandis. Chemosphere 229:434-42.
Scott WC, Breed CS, Haddad SP, Burket SR, Saari GN, Pearce PJ, Chambliss CK, Brooks BW. (2019) Spatial and temporal influence of onsite wastewater treatment systems, centralized effluent discharge, and tides on aquatic hazards of nutrients, indicator bacteria, and pharmaceuticals in a coastal bayou. Science of the Total Environment 650:354-64.
Mills MG, Ramsden R, Ma EY, Corrales J, Kristofco LA, Steele WB, Saari GN, Melnikov F, Kostal J, Kavanagh TJ, Zimmerman JB, Voutchkova-Kostal AM, Brooks BW, Coish P, Anastas PT, Gallagher E (2019) CRISPR-generated Nrf2a loss-and gain-of-function mutants facilitate mechanistic analysis of chemical oxidative stress-mediated toxicity in zebrafish. Chemical Research in Toxicology 33(2):426-435.
Saari GN, Corrales J, Haddad S, Chambliss CK, Brooks BW. (2018) Influence of diltiazem on fathead minnows across dissolved oxygen gradients. Environmental Toxicology and Chemistry 37:2835-2850.
Haddad SP, Luek A, Scott WC, Saari GN, Burket SR, Kristofco LA, Corrales J, Rasmussen JB, Chambliss CK, Luers M, Rogers C, Brooks BW (2018) Spatio-temporal bioaccumulation and trophic transfer of ionizable pharmaceuticals in a semi-arid urban river influenced by snowmelt. Journal of hazardous materials 359:231-40
Steele WB, Kristofco LA, Corrales J, Saari GN, Haddad SP, Gallagher EP, Kavanagh TJ, Kostal J, Zimmerman JB, Voutchkova-Kostal A, Anastas P and Brooks BW (2018) Comparative behavioral toxicology of two common larval fish models: Exploring relationships among modes of action and locomotor responses. Science of the Total Environment 640:1587-1600.
Saari GN, Wang Z, Brooks BW. 2018. Revisiting inland hypoxia: Diverse exceedances of dissolved oxygen thresholds for freshwater aquatic life. Environmental Science and Pollution Research 25:3139–3150. DOI: 10.1007/s11356-017-8908-6
Coish P, Brooks BW, Gallagher EP, Mills M, Kavanagh TJ, Simcox N, Lasker GA, Botta D, Schmuck SC, Voutchkova-Kostal A, Kostal J, Mullins ML, Nesmith SN, Mellor KE, Corrales J, Kristofco L, Saari G, Steele WB, Shen LQ, Melnikov F, Zimmerman JB, Anastas PT. 2018. The Molecular Design Research Network. Toxicological Sciences 161: 241-248.
Mellor KE, Coish P, Brooks BW, Gallagher EP, Mills M, Kavanagh TJ, Simcox N, Lasker GA, Botta D, Schmuck SC, Voutchkova-Kostal A, Kostal J, Mullins ML, Nesmith SM, Corrales J, Kristofco L, Saari G, Steele WB, Melnikov F, Zimmerman JB, Anastas PT. 2018. The Safer Chemical Design Game. Gamification of green chemistry and safer chemical design concepts for high school and undergraduate students. Green Chemistry Letters and Reviews 11: 103-110.
Saari GN, Scott WC, Brooks BW. 2017. Global Scanning Assessment of Calcium Channel Blockers in the Environment: Review and Analysis of Occurrence, Ecotoxicology and Hazards in Aquatic Systems. Chemosphere 189: 466-478.
Corrales J, Kristofco LA, Steele WB, Saari GN, Kostal J, Williams ES, Mills M, Gallagher EP, Kavanagh TJ, Simcox N, Shen LQ, Melnikov F, Zimmerman JB, Voutchkova-Kostal AM, Anastas PT, and Brooks BW. 2017. Towards the design of less hazardous chemicals: Exploring comparative oxidative stress in two common animal models. Chemical Research in Toxicology 30: 893-904.
Haddad SP, Du B, Scott CS, Saari GN, Breed C, Kelly M, Broach L, Chambliss CK, Brooks BW. 2017. Ontogenetic dietary shifts and bioaccumulation of diphenhydramine in Mugil cephalus from an urban estuary. Marine Environmental Research 127: 155-162.
Scott WC, Du B, Haddad SP, Breed C, Saari GN, Kelly M, Broach L, Chambliss CK, Brooks BW. 2016. Spatiotemporal Influences on Emerging Water Quality Indicators: Predicted and Observed Therapeutic Dose Exceedances of Ionizable Pharmaceuticals in Fish Plasma from Urban Coastal Systems. Environmental Toxicology and Chemistry 35:983-995
Du B, Haddad SP, Luek A, Scott CS, Saari GN, Burket SR, Kelly M, Broach L, Rasmussen JB, Chambliss CK, Brooks BW. 2016. Bioaccumulation of ionizable pharmaceuticals in fish across habitats of a tidally-influenced urban bayou. Environmental Toxicology and Chemistry 35: 966-974.
Du B, Haddad SP, Luek A, Scott WC, Saari GN, Kristofco LA, Connors KA, Rash C, Rasmussen JB, Chambliss CK, Brooks B W. 2014. Bioaccumulation and trophic dilution of human pharmaceuticals across trophic positions of an effluent-dependent wadeable stream. Philosophical Transactions of the Royal Society B: Biological Sciences, 369(1656), 20140058.
**Disclaimer: The views expressed in Non-USGS publications are those of the author and do not represent the views of the USGS, Department of the Interior, or the U.S. Government.