This dataset contains pesticide and pharmaceutical results (including maximum and median summaries) collected in the Southeast Region of the United States, 2015-17. Water-quality and bed-sediment results are reported. Samples were analyzed at the National Water Quality Laboratory, Denver, Colorado and the Organic Chemistry Research Laboratory, Sacramento, California. Method and site information is also included. Exposure Activity Ratios were also calculated using ToxCast (https://www.epa.gov/chemical-research/toxcast-dashboard).