Invasive species are a substantial threat to native plants and wildlife, human health and economies, cultural heritage, and commercial, agricultural, and recreational activities. A national early detection and rapid response (EDRR) framework for invasive species is a coordinated and strategic set of actions to find and eradicate initial invasive species infestations before they spread and cause harm, thereby protecting the Nation’s lands and waters and the communities they support. To help advance such a framework, the Department of the Interior (DOI) is working across its bureaus and with other federal agencies, states, tribes, territories, and other partners to identify, enhance, and collaborate on EDRR activities, build new tools, and support coordinated processes to proactively find and eradicate new invasive species before they establish, spread and cause harm. This presentation will focus on the early detection portion of the framework. Providing project updates on the global horizon scans to identify potentially risky species in trade,  an invasion hotspot assessment for the U.S., and the Southeast U.S. pilot surveillance project to implement the framework.