Immunomodulation

The USGS is investigating the effects of 6PPD-quinone (6PPDQ), a harmful contaminant found in urban stormwater runoff, on fish and wildlife health, particularly in salmonids. Recent studies have shown that 6PPDQ poses acute toxicity risks, especially to coho salmon, with sensitivity varying by life stage. New research evaluated the lethal and sublethal impacts of 6PPDQ exposure on coastal...

The USGS Environmental Health Program seeks to understand how environmental factors, especially contaminants and pathogens, influence human health and ecosystems. It focuses on studying the distribution and effects of toxic substances, environmental stressors, and their pathways. The program prioritizes collaboration with State, Federal and local governments; Tribes; non-government organizations...

About the Laboratory The Environmental Health Program collaborates with scientists at the Organic Geochemistry Research Laboratory (OGRL) in Lawrence, Kansas, to develop and employ targeted and non-targeted analytical methods for identification and quantitation of known and understudied algal/cyanobacterial toxins. The laboratory contructed in 2019 is a 2,500 square foot modern laboratory facility...

The Immunomodulation Integrated Science Team focuses on contaminant and pathogen exposures in the environment that might influence the immune systems of wildlife and the connection to their shared environment with humans. In collaboration with public-health officials, the Team also addresses potential human-health risks stemming from similar exposures. If actual risks are identified, this Team...

Tire and road wear particles have been shown to cause acute effects to sensitive aquatic animals and degrade their habitats. U.S. Geological Survey (USGS) scientists developed methods to accurately identify aquatic compounds, such as 6PPD and 6PPD-quinone, that can cause acute mortality events in coho salmon (Oncorhynchus kisutch).

About the Research The Photomicroscopy and Flow Cytometry Core Technology Team (CTT) as part of the Environmental Health Program works to develop and apply biomarkers to evaluate the potential impacts of environmental contaminants at cellular and molecular levels. Because molecular and biochemical responses of cells are preceded by chemical changes in nuclei, cytoplasm, membranes, and...

About the Research The Functional and Molecular Bioassay Core Technology Team (CTT) as part of the Environmental Health Program utilizes reporter assays, quantitative gene expression analyses, and high-throughput sequencing methods to produce functional endpoints across a broad scope of environmental topics and sample matrices.

6PPD-quinone is a compound used to make tires more durable and is also linked to toxicity for Coho Salmon and other aquatic species.

The team is determining the movement and behavior of per- and poly-fluoroalkyl substances (PFAS) from their sources in the environment, as they move through exposure pathways in ecosystems including watersheds and aquifers, their incorporation into food webs, and molecular to population scale effects on fish and wildlife. These studies are accomplished at a variety of spatial scales from regional...

Science from the U.S. Geological Survey (USGS) and other entities has shown that a mixture of natural and synthetic estrogens and other similar chemicals are discharged from wastewater treatment plants (WWTPs) to streams and rivers.

Adult frog exposure to pesticides in aquatic and terrestrial habitats was quantified using a novel combination of radio telemetry and passive sampling techniques to better understand factors affecting frog health and survival in agricultural landscapes.

Microbiologists at the Michigan Bacteriological Research Laboratory (MI-BaRL) use a wide array of traditional and modern molecular approaches to evaluate microbial pathogens and antimicrobial resistance pathways in the environment.