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Pesticide prioritization by potential biological effects in tributaries of the Laurentian Great Lakes

December 23, 2022

Watersheds of the Great Lakes Basin (USA/Canada) are highly modified and impacted by human activities including pesticide use. Despite labeling restrictions intended to minimize risks to nontarget organisms, concerns remain that environmental exposures to pesticides may be occurring at levels negatively impacting nontarget organisms. We used a combination of organismal-level toxicity estimates (in vivo aquatic life benchmarks) and data from high-throughput screening (HTS) assays (in vitro benchmarks) to prioritize pesticides and sites of concern in streams at 16 tributaries to the Great Lakes Basin. In vivo or in vitro benchmark values were exceeded at 15 sites, 10 of which had exceedances throughout the year. Pesticides had the greatest potential biological impact at the site with the greatest proportion of agricultural land use in its basin (the Maumee River, Toledo, OH, USA), with 72 parent compounds or transformation products being detected, 47 of which exceeded at least one benchmark value. Our risk-based screening approach identified multiple pesticide parent compounds of concern in tributaries of the Great Lakes; these compounds included: eight herbicides (metolachlor, acetochlor, 2,4-dichlorophenoxyacetic acid, diuron, atrazine, alachlor, triclopyr, and simazine), three fungicides (chlorothalonil, propiconazole, and carbendazim), and four insecticides (diazinon, fipronil, imidacloprid, and clothianidin). We present methods for reducing the volume and complexity of potential biological effects data that result from combining contaminant surveillance with HTS (in vitro) and traditional (in vivo) toxicity estimates. Environ Toxicol Chem 2022;00:1–18. Published 2022. This article is a U.S. Government work and is in the public domain in the USA. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.

Citation Information

Publication Year 2023
Title Pesticide prioritization by potential biological effects in tributaries of the Laurentian Great Lakes
DOI 10.1002/etc.5522
Authors Samantha K. Oliver, Steven R. Corsi, Austin K. Baldwin, Michelle A. Nott, Gerald T. Ankley, Brett R. Blackwell, Daniel L. Villeneuve, Michelle Hladik, Dana W. Kolpin, Luke C. Loken, Laura A. DeCicco, Michael T. Meyer, Keith Loftin
Publication Type Article
Publication Subtype Journal Article
Series Title Environmental Toxicology and Chemistry
Index ID 70239202
Record Source USGS Publications Warehouse
USGS Organization Kansas Water Science Center; Wisconsin Water Science Center; WMA - Integrated Information Dissemination Division