Keith A Loftin, Ph.D.
Science and Products
Mixtures of Algal Toxins Present Prior to and After Formation of Visible Algal Blooms—Science to Inform the Timing of Algal Toxin Exposure
Cyanobacteria with toxin-producing potential, genes indicating an ability for toxin synthesis, or cyanotoxins were present before and after formation of a visible algal bloom in Kabetogama Lake, a popular recreation area in Voyageurs National Park that lies along the border of Minnesota and Canada. The temporal patterns observed in this study indicate that sampling only when there is a visible...
Understanding Drivers of Cyanotoxin Production in the Lake Okeechobee Waterway
The U.S. Geological Survey (USGS) and other researchers combined field and laboratory approaches in two studies to understand the factors that drive cyanobacterial bloom development and associated cyanotoxin production in Lake Okeechobee, the St. Lucie River and Estuary, and the Indian River Lagoon in response to the large-scale Lake Okeechobee cyanobacteria bloom in 2016.
Toxins and Harmful Algal Blooms Science Team
Algal blooms frequently occur in our Nation's water resources and can cause economic, ecologic and human health concerns. Natural toxins produced by cyanobacteria and other microorganisms are commonly associated with algal blooms. Yet, the actual health threats posed to the public, pets, livestock, and wildlife by these toxins in water resources used for recreation and drinking water remain...
Algal and Other Environmental Toxins Laboratory — Lawrence, Kansas
About the Laboratory
Scientists at the Organic Geochemistry Research Laboratory (OGRL) in Lawrence, Kansas, develop and employ targeted and non-targeted analytical methods for identification and quantitation of known and understudied algal/cyanobacterial toxins that can impact the health of humans and other organisms. Newly acquired (2018) instrumentation will expand...
Understanding Associations between Mussel Productivity and Cyanotoxins in Lake Erie
Study findings indicate that cyanobacteria and cyanotoxins were not associated with mussel mortality at the concentrations present in Lake Erie during a recent study (2013-15), but mussel growth was lower at sites with greater microcystin concentrations.
New Method Developed to Quantify Spatial Extent of Cyanobacterial Blooms
This study provides a method for quantifying changes in the spatial extent of cyanobacterial blooms at local and regional scales using remotely sensed data to determine if bloom occurrence and size are increasing or decreasing for inland water resources.
Satellite Imagery Used to Measure Algal Bloom Frequency—Steps Toward Understanding Exposure Risk
Study explores the utility and limitations of currently available remotely sensed satellite data for identifying the frequency of algal blooms in the Nation's lakes and reservoirs. This information provides a first step toward the goal of understanding exposure risk to protect the health of humans, pets, livestock, and wildlife.
Cyanobacteria from 2016 Lake Okeechobee Harmful Algal Bloom Photo-Documented
New report provides photographic documentation and identification of the cyanobacteria present in Lake Okeechobee, the Caloosahatchee River, and St. Lucie Canal during an extensive algal bloom in 2016.
Evaluating Linkages Between Algal Toxins and Human Health
The amino acid β-methylamino-L-alanine (BMAA) is produced by cyanobacteria and has been suggested by human health researchers as a causal factor for degenerative neurological diseases such as Amyotrophic Lateral Sclerosis (ALS), Parkinsonism, and dementia. An objective review concluded that this hypothesis is not supported by existing data.
USGS Scientist Receives Award for Assistance with National Wetlands Assessment
U.S. Geological Survey (USGS) scientist Dr. Keith A. Loftin received the U.S. Environmental Protection Agency (EPA) Office of Water's Achievement in Science and Technology Award for his contributions to the National Wetlands Condition Assessment.
Analytical Capabilities, Sample Requirements, and Instrumentation
OGRL works independently or collaboratively to pair fate and transport with biological
experiments and effects. OGRL has three main focuses:
1. Development and modification of robust analytical methods needed for analysis of
compounds in multiple matrices to address relevant environmental health issues.
2. Conduct independent and collaborative lab to national based...
OGRL Algal Toxins Methods of Analysis
Algal toxins are a group of toxic compounds produced by a range of photosynthetic freshwater and marine plankton. These toxins have the ability to cause sickness in animals and humans and in severe cases lead to death. OGRL has the ability to evaluate and conduct occurrence, fate, transport, effects, and treatability studies methods.
The presence of antibiotic resistance genes in coastal soil and sediment samples from the eastern seaboard of the USA
Infections from antibiotic resistant microorganisms are considered to be one of the greatest global public health challenges that result in huge annual economic losses. While genes that impart resistance to antibiotics (AbR) existed long before the discovery and use of antibiotics, anthropogenic uses of antibiotics in agriculture, domesticated...
Griffin, Dale W.; Benzel, William M.; Fisher, Shawn C.; Focazio, Michael J.; Iwanowicz, Luke R.; Loftin, Keith A.; Reilly, Timothy J.; Jones, Daniel K. Organic geochemistry and toxicology of a stream impacted by unconventional oil and gas wastewater disposal operations
Water and sediment extracts samples were analyzed for extractable hydrocarbons by gas chromatography/mass spectrometry (GC/MS) using an Agilent (Agilent Technologies, Palo Alto, CA, USA) 7890 series GC and 5975 electron ionization (EI) mass selective detector (MSD) operated in scan mode. Agilent ChemStation software was used for data acquisition...
Orem, William H.; Varonka, Matthew S.; Crosby, Lynn M.; Haase, Karl B.; Loftin, Keith A.; Hladik, Michelle; Akob, Denise M.; Tatu, Calin; Mumford, Adam C.; Jaeschke, Jeanne B.; Bates, Anne L.; Schell, Tiffani; Cozzarelli, Isabelle M.
Methods used for the collection and analysis of chemical and biological data for the Tapwater Exposure Study, United States, 2016–17
In 2016, the U.S. Geological Survey (USGS) Environmental Health Mission Area, initiated the Tapwater Exposure Study as part of an infrastructure project to assess human exposure to potential threats from complex mixtures of contaminants. In the pilot phase (2016), samples were collected from 11 States throughout the United States, and in the...
Romanok, Kristin M.; Kolpin, Dana W.; Meppelink, Shannon M.; Argos, Maria; Brown, Juliane B.; Devito, Michael J.; Dietze, Julie E.; Givens, Carrie E.; Gray, James L.; Higgins, Christopher P.; Hladik, Michelle L.; Iwanowicz, Luke R.; Loftin, Keith A.; McCleskey, R. Blaine; McDonough, Carrie A.; Meyer, Michael T.; Strynar, Mark J.; Weis, Christopher P.; Wilson, Vickie S.; Bradley, Paul M.
Understanding the effect of salinity tolerance on cyanobacteria associated with a harmful algal bloom in Lake Okeechobee, Florida
In an effort to simulate the survival of cyanobacteria asthey are transported from Lake Okeechobee to the estuarinehabitats that receive waters from the lake, a bioassayencompassing a range of salinities was performed. An overalldecline in cyanobacteria health in salinity treatments greaterthan 18 practical salinity units (psu) was indicated by...
Rosen, Barry H.; Loftin, Keith A.; Graham, Jennifer L.; Stahlhut, Katherine N.; Riley, James M.; Johnston, Brett D.; Senegal, Sarena
Water-quality conditions with an emphasis on cyanobacteria and associated toxins and taste-and-odor compounds in the Kansas River, Kansas, July 2012 through September 2016
Cyanobacteria cause a multitude of water-quality concerns, including the potential to produce toxins and taste-and-odor compounds that may cause substantial economic and public health concerns, and are of particular interest in lakes, reservoirs, and rivers that are used for drinking-water supply. Extensive cyanobacterial blooms typically do not...
Graham, Jennifer L.; Foster, Guy M.; Williams, Thomas J.; Mahoney, Matthew D.; May, Madison R.; Loftin, Keith A. Book review: Handbook of cyanobacterial monitoring and cyanotoxin analysis
Review of Meriluoto, Jussi, Lisa Spoof, and GeoffreyA. Codd [eds.]. 2017. Handbook of Cyanobacterial Monitoring and Cyanotoxin Analysis. John Wiley & Sons, Ltd.: Chichester, West Sussex, UK, ISBN 978‐1‐119‐06868‐6 (978‐1‐119‐06876‐1 eBook), DOI 10.1002/9781119068761.
Graham, Jennifer L.; Loftin, Keith A. Associations between cyanobacteria and indices of secondary production in the western basin of Lake Erie
Large lakes provide a variety of ecological services to surrounding cities and communities. Many of these services are supported by ecological processes that are threatened by the increasing prevalence of cyanobacterial blooms which occur as aquatic ecosystems experience cultural eutrophication. Over the past 10 yr, Lake Erie experienced...
Larson, James H.; Evans, Mary Anne; Kennedy, Robert J.; Bailey, Sean; Loftin, Keith A.; Laughrey, Zachary; Femmer, Robin; Schaeffer, Jeff; Richardson, William B.; Wynne, Timothy; Nelson, J. C.; Duris, Joseph W.
Detection of microcystin and other cyanotoxins in lakes at Isle Royale National Park, Pictured Rocks National Lakeshore, and Sleeping Bear Dunes National Lakeshore, northern Michigan, 2012–13
Although cyanotoxins released during algal blooms have become an increasing concern in surface waters across the United States, the presence of cyanotoxins in northern Michigan lakes had not been evaluated in detail. The U.S. Geological Survey and National Park Service (NPS) led a 2-year study (2012 and 2013) to determine the presence of...
Fuller, Lori M.; Brennan, Angela K.; Fogarty, Lisa R.; Loftin, Keith A.; Johnson, Heather E.; VanderMeulen, David D.; Lafrancois, Brenda Moraska Satellite monitoring of cyanobacterial harmful algal bloom frequency in recreational waters and drinking water sources
Cyanobacterial harmful algal blooms (cyanoHAB) cause extensive problems in lakes worldwide, including human and ecological health risks, anoxia and fish kills, and taste and odor problems. CyanoHABs are a particular concern in both recreational waters and drinking water sources because of their dense biomass and the risk of exposure to toxins....
Clark, John M.; Schaeffer, Blake A.; Darling, John A.; Urquhart, Erin A. ; Johnston, John M.; Ignatius, Amber R.; Myer, Mark H.; Loftin, Keith A.; Werdell, P. Jeremy; Stumpf, Richard P. A method for examining temporal changes in cyanobacterial harmful algal bloom spatial extent using satellite remote sensing
Cyanobacterial harmful algal blooms (CyanoHAB) are thought to be increasing globally over the past few decades, but relatively little quantitative information is available about the spatial extent of blooms. Satellite remote sensing provides a potential technology for identifying cyanoHABs in multiple water bodies and across geo-political...
Urquhart, Erin A. ; Schaeffer, Blake A.; Stumpf, Richard P. ; Loftin, Keith A.; Werdell, P. Jeremy A critical review of the postulated role of the non-essential amino acid, β-N-methylamino-L-alanine, in neurodegenerative disease in humans
The compound BMAA (β-N-methylamino-L-alanine) has been postulated to play a significant role in four serious neurological human diseases: Amyotrophic Lateral Sclerosis/Parkinsonism Dementia Complex (ALS/PDC) found on Guam, and ALS, Parkinsonism, and dementia that occur globally. ALS/PDC with symptoms of all three diseases first came to the...
Chernoff, Neil; Hill, D. J.; Diggs, D. L.; Faison, B. D.; Francis, B. M.; Lang, J. R.; Larue, M. M.; Le, T.-T.; Loftin, Keith A.; Lugo, J. N.; Schmid, J. E.; Winnik, W. W.
Cyanobacteria of the 2016 Lake Okeechobee and Okeechobee Waterway harmful algal bloom
The Lake Okeechobee and the Okeechobee Waterway (Lake Okeechobee, the St. Lucie Canal and River, and the Caloosahatchee River) experienced an extensive harmful algal bloom within Lake Okeechobee, the St. Lucie Canal and River and the Caloosahatchee River in 2016. In addition to the very visible bloom of the cyanobacterium Microcystis aeruginosa,...
Rosen, Barry H.; Davis, Timothy W.; Gobler, Christopher J.; Kramer, Benjamin J.; Loftin, Keith A.
New Science Challenges Old Assumptions about Harmful Algal Blooms
First-of-its-kind survey shows that algal toxins are found nationwide