Paula Henry is a research physiologist at the Eastern Ecological Science Center at the Patuxent Research Refuge in Laurel, MD.
Her areas of research focus on sublethal effects of envionmental contaminant exposure on avian, amphibian and reptilian physiology, endocrine systems and behaviors. Her work seeks to integrate laboratory, pen, and field studies for evaluating relative sensitivities of wildlife exposed to environmental pollutants including metals, pesticides, agricultural additives, and industrial chemicals.
Professional Experience
Research Physiologist, Biologist - Department of the Interior: FWS, NBS, USGS (1987-present)
Biological Technician - Department of Defense; Uniforme Services University of the Health Sciences (1984-1987)
Education and Certifications
Ph.D. in Marine Estuarine Environmental Science, University of Maryland, College Park, MD
M.S. in Zoology and Endocrinology, University of Maryland, College Park, MD
B.A. French Literature and Art Historu, Reed College in Portland Oregon.
Affiliations and Memberships*
Society for Environmental Toxicology and Chemistry
Honors and Awards
Scientific Achievement Award: Coauthor on Publication of Significance 1997
Chesapeake and Potomac Regional Chapter, SETAC. Graduate Student Research Award 1996.
USFWS and US EPA Graduate Student Research Assistantship 1982
Science and Products
Hepatic gene expression profiling of American kestrels (Falco sparverius) exposed in ovo to three alternative brominated flame retardants
Three steps to minimize wildlife disease transmission via construction equipment
Thyroid disruption and oxidative stress in American kestrels following embryonic exposure to the alternative flame retardants, EHTBB and TBPH
Sex- and developmental stage-related differences in the hepatic transcriptome of Japanese quail (Coturnix japonica) exposed to 17β-Trenbolone
Endocrine and physiological responses of hatchling American kestrels (Falco sparverius) following embryonic exposure to technical short-chain chlorinated paraffins (C10-13)
Minimizing the spread of aquatic herpetofaunal pathogens by decontaminating construction equipment
In ovo exposure to brominated flame retardants Part II: Assessment of effects of TBBPA-BDBPE and BTBPE on hatching success, morphometric and physiological endpoints in American kestrels
In ovo exposure to brominated flame retardants Part I: Assessment of effects of TBBPA-BDBPE on survival, morphometric and physiological endpoints in zebra finches
Toxicokinetics of imidacloprid-coated wheat seeds in Japanese quail (Coturnix japonica) and an evaluation of hazard
Sex‐specific responses in neuroanatomy of hatchling American kestrels in response to embryonic exposure to the flame retardants bis(2‐ethylhexyl)‐2,3,4,5‐tetrabromophthalate and 2‐ethylhexyl‐2,3,4,5‐tetrabromobenzoate
Female hatchling American kestrels have a larger hippocampus than males: A link with sexual size dimorphism?
Changes in habitat availability for multiple life stages of diamondback terrapins (Malaclemys terrapin) in Chesapeake Bay in response to sea level rise
Bird Hatchling Development Following Exposure to Environmentally Relevant Levels of Brominated Flame Retardants
Effects of Short Chain Chlorinated Paraffins (SCCPs) on developing birds
Terrestrial wildlife and legacy oil mining on National Wildlife Refuges
Produced water from Marcellus Shale and amphibians
Contaminant-related Activities in Support of Client Agencies in the Department of the Interior
Genomic and Behavioral Effects of the Neonicotinoid Imidacloprid in Birds Exposed Through Pesticide-Coated Seeds
Assessing Toxicogenomics Effects of a Synthetic Androgen on Japanese Quail and the Development of an Avian Vitellogenesis Model
The Role of Japanese Quail in Ecotoxicology
Assessing Adverse Outcomes Associated with Exposure of Birds to Flame Retardants
Do Neonicotinoid Pesticide Seed Coatings Pose a Hazard to Seed-eating Birds?
Toxicity of Polybrominated Diphenyl Ethers and Other Flame Retardants to Wildlife
Poisoning of Migratory Birds at Contaminated Sites
Physiological and Endocrine Responses of Hatchling American Kestrels (Falco sparverius) following Embryonic Exposure to Technical Short-Chain Chlorinated Paraffins (C10-13)
Biomarker responses in American kestrels exposed in ovo to EHTBB and TBPH
Immunological histopathology of American kestrels (Falco sparverius) exposed in ovo to two persistent organic pollutants -- SCCPs and TBBPA-BDBPE
In ovo exposure to brominated flame retardants Part II: Assessment of effects of TBBPA-BDBPE and BTBPE on hatching success, morphometric and physiological endpoints in American kestrels
Science and Products
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Filter Total Items: 29
Hepatic gene expression profiling of American kestrels (Falco sparverius) exposed in ovo to three alternative brominated flame retardants
A number of brominated flame retardants (BFRs) have been reported to interfere with the thyroid signaling pathway and cause oxidative stress in birds, yet the underlying shifts in gene expression associated with these effects remain poorly understood. In this study, we measured hepatic transcriptional responses of 31 genes in American kestrel (Falco sparverius) hatchlings following in ovo exposureAuthorsChristopher G. Goodchild, Natalie K. Karouna-Renier, Ryan P. Braham, Paula F. P. Henry, Robert J. Letcher, Kim J. FernieThree steps to minimize wildlife disease transmission via construction equipment
Aquatic wildlife can be harmed by viruses, bacteria, fungi, and parasites introduced into wetlands. These infectious pathogens can survive in mud, soil, vegetation, and other debris that collect on the bodies and crevices of drivable equipment. Construction and habitat restoration projects can accidentally transport pathogens from a contaminated aquatic habitat into a healthy one. These three steAuthorsJames T. Julian, Paula F. P. Henry, James M. Drasher, Susan D. Jewell, Kathy Michell, Kevin J. Oxenrider, Scott A. Smith, Michael J. RavesiThyroid disruption and oxidative stress in American kestrels following embryonic exposure to the alternative flame retardants, EHTBB and TBPH
Brominated flame retardant chemicals, such as 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (EHTBB) (CAS #: 183658–27-7) and bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate (TBPH) (CAS #: 26040–51-7), have been detected in avian tissues and eggs from remote regions. Exposure to EHTBB and TBPH has been shown to cause oxidative stress and altered thyroid function in rodents and fish, yet no controlled studiAuthorsCHristopher Goodchild, Natalie K. Karouna-Renier, Paula F. P. Henry, Robert J. Letcher, Sandra L. Schultz, Catherine M. Maddox, Thomas Bean, Lisa E. Peters, Vince P. Palace, Kimberly J. FernieSex- and developmental stage-related differences in the hepatic transcriptome of Japanese quail (Coturnix japonica) exposed to 17β-Trenbolone
Endocrine-disrupting chemicals can cause transcriptomic changes that may disrupt biological processes associated with reproductive function including metabolism, transport, and cell growth. We investigated effects from in ovo and dietary exposure to 17β-trenbolone (at 0, 1, and 10 ppm) on the Japanese quail (Coturnix japonica) hepatic transcriptome. Our objectives were to identify differentially eAuthorsKrittika Mittal, Paula F. P. Henry, Robert S. Cornman, Catherine M. Maddox, Niladri Basu, Natalie K. Karouna-RenierEndocrine and physiological responses of hatchling American kestrels (Falco sparverius) following embryonic exposure to technical short-chain chlorinated paraffins (C10-13)
Short chain chlorinated paraffins (SCCPs) are complex mixtures of polychlorinated n-alkanes, shown to bioaccumulate but with unknown effects in wild birds. The present study examined development-related effects of SCCPs on captive American kestrels (Falco sparverius) treated in ovo on embryonic day (ED) 5 by injection with technical Chloroparaffin® (C10-13, 55.5% Cl) at environmentally relevant noAuthorsKim J. Fernie, Natalie K. Karouna-Renier, R. J. Letcher, Sandra L. Schultz, L. E. Peters, V. Palace, Paula F. P. HenryMinimizing the spread of aquatic herpetofaunal pathogens by decontaminating construction equipment
Some problems have relatively simple solutions compared to the cost of neglect. Preventing the spread of invasive species and harmful pathogens clinging to construction equipment is one such solution. Here we explain how resource managers and contractors can decontaminate construction and field equipment by cleaning, disinfecting, and drying, thus minimizing the spread of harmful organisms.AuthorsJames T. Julian, Paula F. P. Henry, James M. Drasher, Kathy Michell, Scott A. SmithIn ovo exposure to brominated flame retardants Part II: Assessment of effects of TBBPA-BDBPE and BTBPE on hatching success, morphometric and physiological endpoints in American kestrels
Tetrabromobisphenol A bis(2,3-dibromopropyl ether) (TBBPA-BDBPE) and 1,2-bis(2,4,6-tribromophenoxy)ethane (BTPBE) are both brominated flame retardants (BFRs) that have been detected in birds; however, their potential biological effects are largely unknown. We assessed the effects of embryonic exposure to TBBPA-BDBPE and BTBPE in a model avian predator, the American kestrel (Falco sparverius). FertAuthorsMargaret Eng, Natalie K. Karouna-Renier, Paula F. P. Henry, Robert J. Letcher, Sandra L. Schultz, Thomas G. Bean, Lisa E. Peters, Vince P. Palace, Tony D. Williams, John E. Elliott, Kim J. FernieIn ovo exposure to brominated flame retardants Part I: Assessment of effects of TBBPA-BDBPE on survival, morphometric and physiological endpoints in zebra finches
Tetrabromobisphenol A bis(2,3-dibromopropyl) ether (TBBPA-BDBPE) is an additive flame retardant used in polyolefins and polymers. It has been detected in biota, including in avian eggs, yet little is known of its effects. We assessed the pattern of TBBPA-BDBPE concentrations in songbird eggs over the incubation period, and the effects of embryonic exposure to TBBPA-BDBPE in a model songbird specieAuthorsMargaret Eng, Tony D. Williams, Kim J. Fernie, Natalie K. Karouna-Renier, Paula F. P. Henry, Robert J. Letcher, John E. ElliottToxicokinetics of imidacloprid-coated wheat seeds in Japanese quail (Coturnix japonica) and an evaluation of hazard
Birds are potentially exposed to neonicotinoid insecticides by ingestion of coated seeds during crop planting. Adult male Japanese quail were orally dosed with wheat seeds coated with an imidacloprid (IMI) formulation at either 0.9 mg/kg body weight (BW) or 2.7 mg/kg BW (~3 and 9% of IMI LD50 for Japanese quail, respectively) for 1 or 10 days. Quail were euthanized between 1 and 24 h post-exposureAuthorsThomas G. Bean, Michael S. Gross, Natalie K. Karouna-Renier, Paula F. P. Henry, Sandra L. Schultz, Michelle Hladik, Kathryn Kuivila, Barnett A. RattnerSex‐specific responses in neuroanatomy of hatchling American kestrels in response to embryonic exposure to the flame retardants bis(2‐ethylhexyl)‐2,3,4,5‐tetrabromophthalate and 2‐ethylhexyl‐2,3,4,5‐tetrabromobenzoate
Bis(2‐ethylhexyl)‐2,3,4,5‐tetrabromophthalate (BEH‐TEBP) and 2‐ethylhexyl‐2,3,4,5‐tetrabromobenzoate (EH‐TBB), flame retardant components of FireMaster 550® and 600® have been detected in tissues of wild birds. To address the paucity of information regarding potential impacts of flame retardants on the brain, brain volume regions of hatchling American kestrels (Falco sparverius) were evaluated folAuthorsMélanie F. Guigueno, Natalie K. Karouna-Renier, Paula F. P. Henry, Lisa E. Peters, Vince P. Palace, Robert J. Letcher, Kim J. FernieFemale hatchling American kestrels have a larger hippocampus than males: A link with sexual size dimorphism?
The brain and underlying cognition may vary adaptively according to an organism’s ecology. As with all raptor species, adult American kestrels (Falco sparverius) are sexually dimorphic with females being larger than males. Related to this sexual dimorphism, kestrels display sex differences in hunting and migration, with females ranging more widely than males, suggesting possible sex differences inAuthorsMelanie F. Guigueno, Natalie K. Karouna-Renier, Paula F. P. Henry, Jessica A. Head, Lisa E. Peters, Vince P. Palace, Robert J. Letcher, Kimberly J. FernieChanges in habitat availability for multiple life stages of diamondback terrapins (Malaclemys terrapin) in Chesapeake Bay in response to sea level rise
Global sea level rise (SLR) will significantly alter coastal landscapes through inundation and erosion of lowlying areas. Animals that display area fidelity and rely on fringing coastal habitats during multiple life stages, such as diamondback terrapins (Malaclemys terrapin Schoepff 1793), are likely to be particularly vulnerable to SLR-induced changes. We used a combination of empirical nest survAuthorsRyan J. Woodland, Christopher L. Rowe, Paula F. P. Henry - Science
Filter Total Items: 14
Bird Hatchling Development Following Exposure to Environmentally Relevant Levels of Brominated Flame Retardants
Scientists performed laboratory studies with American kestrels and zebra finch to determine the effects of brominated flame retardant exposure on hatchlings. They found evidence that exposure while in the egg disrupted thyroid function in female American kestrel hatchlings and affected nestling body condition in zebra finch hatchlings, but no other effects were detected.Effects of Short Chain Chlorinated Paraffins (SCCPs) on developing birds
The Challenge: Short-Chain Chlorinated Paraffins (SCCPs) are complex technical mixtures of polychlorinated n-alkanes used in lubricants and coolants in metalworking, as flame retardants, and in paints, adhesives, sealants, textiles and polymeric materials, plastics and rubber. SCCPs are of concern because they are globally transported, bioaccumulate in wildlife and humans, and are environmentally...Terrestrial wildlife and legacy oil mining on National Wildlife Refuges
Amphibian surveys are being conducted on select National Wildlife Refuges with active and/or legacy oil mining to determine species relative distribution and their risk to short- and long-term effects from exposure to crude oil and its byproducts.Produced water from Marcellus Shale and amphibians
Research biologists at the USGS Eastern Ecological Science Center at the Patuxent Research Refuge are conducting a series of scientific studies on the potential effects of wastewater from hydraulic fracturing activities on terrestrial wildlife. Findings will help in assessing proposals for managing recycling and distribution of large volumes of flowback and produced waters generated by methods of...Contaminant-related Activities in Support of Client Agencies in the Department of the Interior
We undertake many research activities in support of the mission of the Department of the Interior. One such activity is to evaluate the potential hazard and risk of environmental contaminants to natural resources.Genomic and Behavioral Effects of the Neonicotinoid Imidacloprid in Birds Exposed Through Pesticide-Coated Seeds
The Challenge: Neonicotinoid pesticides act as agonists of nicotinic acetylcholine receptors (nAChRs) and are designed to be lethal to insects while theoretically posing little to no threat to vertebrates. The perceived safety of neonicotinoids has led to a sharp increase in their use in the United States and globally, since they were first introduced in 1994. The use of the neonicotinoid...Assessing Toxicogenomics Effects of a Synthetic Androgen on Japanese Quail and the Development of an Avian Vitellogenesis Model
The Challenge: Endocrine active chemicals (EAC) are known to interfere with hormonally regulated physiological processes, thereby affecting signaling in the hypothalamic-pituitary-gonadal-liver (HPGL) axis and commonly resulting in reproductive dysfunction. Computational models that relate hormonal and genomic biomarkers within the HPGL axis to the reproductive cycle and ecologically relevant...The Role of Japanese Quail in Ecotoxicology
The Challenge: Wild birds are exposed throughout their lives to natural and synthetic chemicals that are present in the environment, many of which interfere with the animal’s physiological and developmental systems. Relative concentrations, routes, frequency, and the environment in which chemical exposure occurs will determine to a large extent the bird’s response. Well-designed avian field...Assessing Adverse Outcomes Associated with Exposure of Birds to Flame Retardants
The Challenge: The use of flame retardants (FRs) as additives in a variety of consumer use products, including plastics, textiles, and electronics, is projected to continue and increase for the foreseeable future. Because of unanticipated environmental problems, some FRs have either been banned, restricted, or are being phased-out and replaced by other new and presumably safer FRs. Regrettably...Do Neonicotinoid Pesticide Seed Coatings Pose a Hazard to Seed-eating Birds?
Treating or “dressing” of seeds with pesticides is a commonly used method to enhance crop yield in agriculture. Regrettably, such treated seeds can be ingested by wildlife, and depending on the extent of exposure, can cause adverse effects.Toxicity of Polybrominated Diphenyl Ethers and Other Flame Retardants to Wildlife
Flame retardants are a class of commonly used household and industrial products. Because of widespread use, there is concern that their presence in the environment can potentially pose a hazard and risk to wildlife.Poisoning of Migratory Birds at Contaminated Sites
The Challenge: The Department of the Interior (DOI) and the National Oceanic & Atmospheric Administration are trustees for a wide variety natural resources that belong to all Americans. Additional natural resources are overseen by Native American tribes, states, and other federal agencies. Migratory birds are an example of a trust species for DOI, under the US Fish and Wildlife Service. When wild... - Data
Physiological and Endocrine Responses of Hatchling American Kestrels (Falco sparverius) following Embryonic Exposure to Technical Short-Chain Chlorinated Paraffins (C10-13)
- Observations of test subjects and hatching data - Body weight, organ/tissue weights - Biomarker data (oxidative stress indicators, oxidative DNA damage, thyroid hormones, histological findings) in various tissues - Chemical residues in tissuesBiomarker responses in American kestrels exposed in ovo to EHTBB and TBPH
Observations of test subjects and hatching data - Body weight, organ/tissue weights Biomarker data (oxidative stress indicators, oxidative DNA damage, thyroid hormones, histological findings) in various tissues Chemical residues in tissuesImmunological histopathology of American kestrels (Falco sparverius) exposed in ovo to two persistent organic pollutants -- SCCPs and TBBPA-BDBPE
This work is part of a study of the immunological effects of exposure to alternative flame retardants in avian species. For the pathology portion of the study, spleens and bursas from American kestrels (Falco sparverius) exposed by egg injection to varying doses of short-chain chlorinated paraffins (SCCPs) and the flame retardant TBBPA-BDBPE were examined microscopically for architectural and cellIn ovo exposure to brominated flame retardants Part II: Assessment of effects of TBBPA-BDBPE and BTBPE on hatching success, morphometric and physiological endpoints in American kestrels
- Observations of test subjects and hatching data - Body weight, organ/tissue weights - Biomarker data (oxidative stress indicators, oxidative DNA damage, thyroid hormones, histological findings) in various tissues - Chemical residues in tissues - Multimedia
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*Disclaimer: Listing outside positions with professional scientific organizations on this Staff Profile are for informational purposes only and do not constitute an endorsement of those professional scientific organizations or their activities by the USGS, Department of the Interior, or U.S. Government