Iwanowicz, L., L Brown, B Eltz, F Juanes and J Murt (2004) Book Review. In a Perfect Ocean: The state of fisheries and ecosystems in the North Atlantic Ocean. Reviews in Fish Biology and Fisheries.14: 149-151.
Luke R Iwanowicz, Ph.D.
Biography
Biography
Dr. Iwanowicz is a research biologist at the USGS, Leetown Science Center, National Fish Health Research Laboratory in Leetown, WV. His primary research focuses on the application of resident fishes as sentinels of aquatic ecosystem health, the development of molecular tools for field study, and the identification of emerging diseases of fishes. He also leads a Core Technology Team established to evaluate environmental water samples for biological activity including endocrine disrupting activity and toxicity.
Education
- Ph.D. 2008, University of Massachusetts, Amherst, Department of Natural Resources, Advisor: Stephen D. McCormick
- M.S. 2000, University of Arkansas at Pine Bluff, Department of Aquaculture/Fisheries, Advisor: Andrew E. Goodwin
- B.S. 1997, University of Massachusetts, Amherst, Major: Fish Biology, Minor: Biology
Professional Experience
- Editorial Board, Environmental Toxicology and Chemistry, 2016-present
- Adjunct Graduate Faculty, University of Maryland, College Park, 2015-present
- Associate Editor, Journal of Aquatic Animal Health, 2009-2017
- Research Biologist, US Geological Survey, Leetown Science Center, 2008-present
- Research Fish Biologist, US Geological Survey, Leetown Science Center, 2006-2008
- Biological Laboratory Technician, US Geological Survey, Leetown Science Center, 2002-2006
- Scientist II, Virginia Institute of Marine Science, 2001-2002
Selected Awards & Recognition
- U.S. Environmental Protection Agency; Scientific and Technological Achievement Award (2015)
- Spotlight Feature Article, Journal of Virology (2015)
- American Fisheries Society, Most significant paper in Journal of Aquatic Animal Health (2011)
- AFS-Fish Health Section; Special Achievement Award (2011)
- American Fisheries Society, Most significant paper in Journal of Aquatic Animal Health (2004)
Professional Societies
- American Association for the Advancement of Science
- American Society for Microbiology
- American Fisheries Society
- Microbiology Society
- Society for Environmental Toxicology and Chemistry
Science and Products
Date published: October 3, 2019
Status: Completed Intersex in Male Smallmouth Bass in the Missisquoi River in Vermont: Understanding Factors that Can Lead to Endocrine Disruption in Field Settings
The presence of testicular oocytes (intersex) in male smallmouth bass (Micropterus dolomieu) in the Missisquoi River in Vermont varied over the period of the study and was not related to concentrations of known endocrine disrupting chemicals in the River. Although previous studies have shown linkages between endocrine disrupting chemical exposures and intersex in fish, these results...
Contacts: Luke R Iwanowicz, Ph.D.
Date published: April 3, 2019
Status: Active An ecosystem approach to assessing unconventional oil and gas impacts in aquatic ecosystems
The development of unconventional oil and gas (UOG) technology promises economic, societal and national security benefits. However, technological developments in this field have rapidly outpaced scientific studies on potential environmental effects. The effects of accidental UOG-related spills on environmental health are not adequately characterized, often occur in already ecological...
Date published: November 29, 2018
Status: Active Human and Ecological Health Impacts Associated with Water Reuse and Conservation Practices
Human and Ecological Health Impacts Associated with Water Reuse and Conservation Practices
Contacts: Luke R Iwanowicz, Ph.D.
Attribution: Ecosystems, Leetown Science Center
Date published: November 29, 2018
Status: Completed Molecular characterization of unknown virus isolated from the introduced species, the Northern snake head (Channa argus), present in the Chesapeake Bay Watershed
Molecular characterization of unknown virus isolated from the introduced species, the Northern snake head (Channa argus), present in the Chesapeake Bay Watershed
Contacts: Luke R Iwanowicz, Ph.D.
Date published: November 29, 2018
Status: Active Endocrine Disrupting Chemicals and Prevalence of Intersex in Fish Populations in New Jersey
Endocrine Disrupting Chemicals and Prevalence of Intersex in Fish Populations in New Jersey
Contacts: Luke R Iwanowicz, Ph.D.
Date published: November 13, 2018
Status: Active Evaluating the pathogenicity and replication of a novel aquareovirus that infects the endangered fountain darter, Etheostoma fonticola
Evaluating the pathogenicity and replication of a novel aquareovirus that infects the endangered fountain darter, Etheostoma fonticola
Contacts: Luke R Iwanowicz, Ph.D.
Attribution: Ecosystems, Leetown Science Center
Date published: November 9, 2018
Status: Active Prevalence of novel, emerging hepatitis viruses in wild white suckers and their association with liver tumors in the Great Lakes region
Prevalence of novel, emerging hepatitis viruses in wild white suckers and their association with liver tumors in the Great Lakes region
Contacts: Luke R Iwanowicz, Ph.D.
Date published: August 29, 2018
Status: Active Functional and Molecular Bioassay Laboratory — Kearneysville, West Virginia
About the Laboratory
The Functional and Molecular Bioassay Laboratory applies and modifies microbial and eukaryotic reporter bioassays to detect the presence of bioactive chemicals from environmental water samples. These analyses compliment analytical chemistry and biological datasets. The laboratory adapts and applies cell isolation and culture methods to measure...
Date published: May 4, 2018
Status: Archived Endocrine Disrupting Chemicals and Prevalence of Intersex in Fish Populations in New Jersey
NJ WSC and Leetown Science Center scientists in cooperation with the New Jersey Department of Environmental Protection were tasked with characterizing endocrine disruption in smallmouth bass from New Jersey.
Contacts: Kelly Smalling, Luke R Iwanowicz, Ph.D., Sandra Goodrow
Date published: June 21, 2016
Status: Completed New Hepatitis B Virus Discovered in White Sucker (Catostomus commersonii)
The first known hepatitis B virus to infect fish (white sucker; Catostomus commersonii) has been discovered by U.S. Geological Survey (USGS) scientists.
Contacts: Luke R Iwanowicz, Ph.D.
Attribution: Environmental Health, Contaminant Biology Program
Date published: February 2, 2015
Status: Completed Channel Catfish (Ictalurus punctatus) White Blood Cells are Functionally Modulated by Estrogens
Estrogens are recognized as modulators of immune responses in mammals, but how these effects might occur in fish was not understood. U.S. Geological Survey (USGS) scientists published findings that fish white blood cells (leukocytes) have specific estrogen receptors (ERs)—a discovery that moves scientists one step closer to understanding the connection between exposure to estrogenic substances...
Contacts: Luke R Iwanowicz, Ph.D.
Attribution: Environmental Health, Contaminant Biology Program
Year Published: 2020
Draft genome of an adomavirus associated with raised mucoid skin lesions on smallmouth bass (Micropterus dolomieu)
Raised mucoid skin lesions have been observed on smallmouth bass (Micropterus dolomieu) for years. Here we report a draft genome of a novel adomavirus (Micropterus dolomieu adomavirus 2) associated with this disease. The circular genome is 17,561 bp and most similar to that of alpha-Adomaviruses.
Iwanowicz, Luke; Young, Kelsey T.; Adams, Cynthia R.; Blazer, Vicki S.; Smith, Geoffrey; Cornman, Robert S.
Year Published: 2020
Reconnaissance of surface water estrogenicity and the prevalence of intersex in smallmouth bass (Micropterus dolomieu) inhabiting New Jersey
The observation of testicular oocytes in male fishes has been utilized as a biomarker of estrogenic endocrine disruption. A reconnaissance project led in the Northeastern United States (US) during the period of 2008–2010 identified a high prevalence of intersex smallmouth bass on or near US Fish & Wildlife Service National Wildlife Refuges...
Iwanowicz, Luke; Smalling, Kelly; Blazer, Vicki S.; Braham, Ryan P.; Sanders, Lakyn R.; Boetsma, Anna; Procopio, Nick; Goodrow, Sandra; Buchanan, Gary; Millemann, Daniel; Ruppel, Bruce; Vile, John; Henning, Brian; Abatemarco, John
Year Published: 2020
Mixed organic and inorganic tapwater exposures and potential effects in greater Chicago area, USA
Safe drinking water at the point of use (tapwater, TW) is a public-health priority. TW exposures and potential human-health concerns of 540 organics and 35 inorganics were assessed in 45 Chicago area United States (US) homes in 2017. No US Environmental Protection Agency (EPA) enforceable Maximum Contaminant Level(s) (MCL) were exceeded in any...
Bradley, Paul; Argos, Maria; Kolpin, Dana W.; Meppelink, Shannon M.; Romanok, Kristin; Smalling, Kelly; Focazio, Michael J.; Allen, Joshua M.; Dietze, Julie E.; Devito, Michael J.; Donovan, Ariel; Evans, Nicola; Givens, Carrie E.; Gray, James L.; Higgins, Christopher P.; Hladik, Michelle; Iwanowicz, Luke; Journey, Celeste A.; Lane, Rachael; Laughrey, Zachary; Loftin, Keith A.; McCleskey, R. Blaine; McDonough, Carrie A.; Medlock Kakaley, Elizabeth K; Meyer, Michael T.; Holthouse-Putz, Andrea; Richardson, Susan D; Stark, Alan ; Weis, Christopher P.; Wilson, Vickie S.; Zehraoui, Abderrahman
Year Published: 2019
Exposure and potential effects of pesticides and pharmaceuticals in protected streams of the US National Park Service southeast Region
Globally protected areas offer refugia for a broad range of taxa including threatened and endangered species. The United States National Park Service (NPS) manages public lands to preserve biodiversity, but increasing park visitation and development of surrounding landscapes increase exposure to and effects from bioactive contaminants. The risk (...
Bradley, Paul; Romanok, Kristin; Duncan, Jeffrey R.; Battaglin, William; Clark, Jimmy; Hladik, Michelle; Huffman, Bradley; Iwanowicz, Luke; Journey, Celeste A.; Smalling, KellyAttribution: Water, California Water Science Center, Colorado Water Science Center, Leetown Science Center, New Jersey Water Science Center, South Atlantic Water Science Center (SAWSC), Ecosystems, Water Resources, Region 1: North Atlantic-Appalachian, Region 2: South Atlantic-Gulf (Includes Puerto Rico and the U.S. Virgin Islands), Region 7: Upper Colorado Basin, United States of America
Year Published: 2019
Influenza A virus detected in native bivalves in waterfowl habitat of the Delmarva Peninsula, USA
We evaluated the prevalence of influenza A virus (IAV) in different species of bivalves inhabiting natural water bodies in waterfowl habitat along the Delmarva Peninsula and Chesapeake Bay in eastern Maryland. Bivalve tissue from clam and mussel specimens (Macoma balthica, Macoma phenax, Mulinia sp., Rangia cuneata, ...
Densmore, Christine L.; Iwanowicz, Deborah D.; McLaughlin, Shawn M.; Ottinger, Christopher A.; Spires, Jason E.; Iwanowicz, Luke R.
Year Published: 2019
Predictive analysis using chemical-gene interaction networks consistent with observed endocrine activity and mutagenicity of U.S. streams
In a recent U.S. Geological Survey/U.S. Environmental Protection Agency study assessing >700 organic compounds in 38 streams, in vitro assays indicated generally low estrogen, androgen, and glucocorticoid receptor activities, but identified 13 surface waters with 17β estradiol equivalent (E2Eq) activities greater than the 1 ng/L level of...
Berninger, Jason P.; DeMarini, David M.; Warren, Sarah H.; Simmons, Jane Ellen; Wilson, Vickie S.; Conley, Justin M.; Armstrong, Mikayla D.; Kolpin, Dana W.; Kuivila, Kathryn; Reilly, Timothy J.; Romanok, Kristin M.; Villeneuve, Daniel L.; Bradley, Paul M.; Iwanowicz, Luke R.Attribution: Columbia Environmental Research Center, Leetown Science Center, New Jersey Water Science Center, Pennsylvania Water Science Center, South Atlantic Water Science Center (SAWSC), Ecosystems, Water Resources, Toxic Substances Hydrology Program, Region 1: North Atlantic-Appalachian, Region 2: South Atlantic-Gulf (Includes Puerto Rico and the U.S. Virgin Islands), Region 4: Mississippi Basin, Pennsylvania, United States of America
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Berninger, J.P., D.M. DeMarini, S.H. Warren, J.E. Simmons, V.S. Wilson, J.M. Conley, M.S. Armstrong, L.R. Iwanowicz, D.W. Kolpin, K.M. Kuivila, T.J. Reilly, K.M. Romanok, D.A. Villeneuve, and P.M. Bradley. 2019. Predictive analysis using chemical-gene interaction networks consistent with observed endocrine activity and mutagenicity of U.S. streams. Environmental Science and Technology. http://dx.doi.org/10.1021/acs.est.9b02990
Year Published: 2019
The presence of antibiotic resistance genes in coastal soil and sediment samples from the eastern seaboard of the USA
Infections from antibiotic resistant microorganisms are considered to be one of the greatest global public health challenges that result in huge annual economic losses. While genes that impart resistance to antibiotics (AbR) existed long before the discovery and use of antibiotics, anthropogenic uses of antibiotics in agriculture, domesticated...
Griffin, Dale W.; Benzel, William M.; Fisher, Shawn C.; Focazio, Michael J.; Iwanowicz, Luke R.; Loftin, Keith A.; Reilly, Timothy J.; Jones, Daniel K.Attribution: Environmental Health, Eastern Geographic Science Center, Geology, Geophysics, and Geochemistry Science Center, Geology, Minerals, Energy, and Geophysics Science Center, Kansas Water Science Center, Leetown Science Center, New Jersey Water Science Center, New York Water Science Center, Pennsylvania Water Science Center, St. Petersburg Coastal and Marine Science Center, Utah Water Science Center, Ecosystems, Environmental Health, Water Resources, Toxic Substances Hydrology Program, Region 1: North Atlantic-Appalachian, Region 2: South Atlantic-Gulf (Includes Puerto Rico and the U.S. Virgin Islands), Region 7: Upper Colorado Basin, Northeast, Pennsylvania, United States of America
Year Published: 2019
Isolation, characterization and molecular identification of a novel aquareovirus that infects the endangered fountain darter, Etheostoma fonticola
The fountain darter Etheostoma fonticola (FOD) is a federally endangered fish listed under the US Endangered Species Act. Here, we identified and characterized a novel aquareovirus isolated from wild fountain darters inhabiting the San Marcos River. This virus was propagated in Chinook salmon embryo (CHSE)-214, rainbow trout gonad-2 and...
Iwanowicz, Luke R.; Iwanowicz, Deborah D.; Adams, Cynthia R.; Lewis, Teresa; Brandt, Tom; Sanders, Lakyn R.; Cornman, Robert S.
Year Published: 2019
Indicators of exposure to estrogenic compounds at Great Lakes Areas of Concern: Species and site comparisons
Adverse effects resulting from potential exposure of wild fishes to estrogenic endocrine disruptors was assessed at seven United States Great Lakes Areas of Concern using biomarkers ranging from organismal (gonadosomatic indices) to tissue/plasma (histology, plasma vitellogenin) and molecular (hepatic gene transcripts) levels. Biomonitoring was...
Blazer, Vicki S.; Walsh, Heather L.; Shaw, Cassidy H.; Iwanowicz, Luke R.; Braham, Ryan P.; Mazik, Patricia
Year Published: 2018
Reconnaissance of mixed organic and inorganic chemicals in private and public supply tapwaters at selected residential and workplace sites in the United States
Safe drinking water at the point-of-use (tapwater, TW) is a United States public health priority. Multiple lines of evidence were used to evaluate potential human health concerns of 482 organics and 19 inorganics in TW from 13 (7 public supply, 6 private well self-supply) home and 12 (public supply) workplace locations in 11 states. Only uranium (...
Bradley, Paul M.; Kolpin, Dana W.; Romanok, Kristin M.; Smalling, Kelly L.; Focazio, Michael J.; Brown, Juliane B.; Cardon, Mary C.; Carpenter, Kurt; Corsi, Steven R.; DeCicco, Laura A.; Dietze, Julie E.; Evans, Nicola; Furlong, Edward T.; Givens, Carrie E.; Gray, James; Griffin, Dale W.; Higgins, Christopher P.; Hladik, Michelle L.; Iwanowicz, Luke R. ; Journey, Celeste A.; Kuivila, Kathryn ; Masoner, Jason R.; McDonough, Carrie A.; Meyer, Michael T.; Orlando, James L.; Strynar, Mark J.; Weis, Christopher P.; Wilson, Vickie S.
Year Published: 2018
Methods used for the collection and analysis of chemical and biological data for the Tapwater Exposure Study, United States, 2016–17
In 2016, the U.S. Geological Survey (USGS) Environmental Health Mission Area, initiated the Tapwater Exposure Study as part of an infrastructure project to assess human exposure to potential threats from complex mixtures of contaminants. In the pilot phase (2016), samples were collected from 11 States throughout the United States, and in the...
Romanok, Kristin M.; Kolpin, Dana W.; Meppelink, Shannon M.; Argos, Maria; Brown, Juliane B.; Devito, Michael J.; Dietze, Julie E.; Givens, Carrie E.; Gray, James L.; Higgins, Christopher P.; Hladik, Michelle L.; Iwanowicz, Luke R.; Loftin, Keith A.; McCleskey, R. Blaine; McDonough, Carrie A.; Meyer, Michael T.; Strynar, Mark J.; Weis, Christopher P.; Wilson, Vickie S.; Bradley, Paul M.Attribution: Environmental Health, Central Midwest Water Science Center, South Atlantic Water Science Center (SAWSC), Environmental Health, Water Resources, Toxic Substances Hydrology Program, Region 2: South Atlantic-Gulf (Includes Puerto Rico and the U.S. Virgin Islands), Illinois, United States of America
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Romanok, K.M., Kolpin, D.W., Meppelink, S.M., Argos, M., Brown, J.B., DeVito, M.J., Dietze, J.E., Givens, C.E., Gray, J.L., Higgins, C.P., Hladik, M.L., Iwanowicz, L.R., Loftin, K.A., McCleskey, R.B., McDonough, C.A., Meyer, M.T., Strynar, M.J., Weis, C.P., Wilson, V.S., and Bradley, P.M., 2018, Methods used for the collection and analysis of chemical and biological data for the Tapwater Exposure Study, United States, 2016–17: U.S. Geological Survey Open-File Report 2018–1098, 79 p., https://doi.org/10.3133/ofr20181098.
Year Published: 2018
A method for determining avian influenza virus hemagglutinin and neuraminidase subtype association
Methods for grouping specific avian influenza virus (AIV) hemagglutinin (HA) and neuraminidase (NA) subtype reverse-transcription polymerase chain reaction (RT-PCR) products into HA:NA subtypes when egg incubation is technically not feasible were evaluated. These approaches were adopted for use as post hoc methods after melt curve analysis. The...
Ottinger, Christopher A.; Iwanowicz, Deborah D.; Iwanowicz, Luke R.; Adams, Cynthia R.; Sanders, Lakyn R.; Densmore, Christine L.View Citation
Ottinger, C.A., Iwanowicz, D.D., Iwanowicz, L.R., Adams, C.R., Sanders, L.R., and Densmore, C.L., 2018, A method for determining avian influenza virus hemagglutinin and neuraminidase subtype association: U.S. Geological Survey Open-File Report 2018–1102, 15 p., https://doi.org/10.3133/ofr20181102.
Pre-USGS Publications
McIntire, M., L R Iwanowicz and A E Goodwin (2003) Molecular, physical and clinical evidence that Golden Shiner Virus (GSV) and Grass Carp Reovirus (GCRV) are variants of the same virus. Journal of Aquatic Animal Health. 15: 257-263.
Iwanowicz, L.R. and A E Goodwin (2002) Characterization of a new bacilliform fathead minnow rhabdovirus that produces syncytia in tissue culture. Archives of Virology 147: 889 – 916.
Iwanowicz, L.R. A E Goodwin and J Harshbarger (2001) Embryonal rhabdomyosarcoma of the giant gourami, Colisa fasciata (Bloch & Schneider). Journal of Fish Diseases 24:177-179
Iwanowicz, L.R. A E Goodwin and N Heil (2000) A small RNA virus isolated from apparently healthy wild sandbar shiners, Notropis scepticus. Journal of Fish Diseases 23: 349-352.