Wildlife Disease and One Health

Chronic wasting disease (CWD) is a contagious and fatal neurodegenerative disease affecting cervids (deer, elk, caribou, and moose) that is threatening the health and sustainability of cervid populations across North America. CWD is caused by misfolded proteins known as prions, which can be transmitted by direct contact or environmental exposure. The USGS National Wildlife Health Center conducts...

At least ten distinct chronic wasting disease (CWD) prion strains with unique biochemical properties affect disease transmission and host range, prompting development and validation of biochemical assays to surveil and track these strains in endemic regions like Wisconsin, with ongoing efforts to standardize these methods for epidemiological tracking and management of CWD variants .

White-nose syndrome (WNS) has killed millions of hibernating bats across North America, causing severe population declines and even local extinctions. Caused by the cold-loving fungus Pseudogymnoascus destructans, this disease behaves unlike typical wildlife pathogens, making it especially hard to control. Researchers at the USGS National Wildlife Health Center, with partners at the University of...

Vampire bats are the primary spreader of rabies, a lethal disease that harms livestock and people across Latin America. Growth of the livestock industry and environmental changes in this region are leading to the expansion of vampire bats’ habitat range, and it is considered likely this species will move into the southern United States.

USGS researchers seek to understand the factors influencing the spread and persistence of avian influenza viruses on the landscape. This research also addresses how novel strains of highly pathogenic avian influenza are impacting a larger number and diversity of host species, including waterfowl, shorebirds, raptors and other birds.

USGS is investigating factors that influence the risk of avian influenza transmission from wild waterfowl to domestic poultry within the Chesapeake Bay region, a hub of poultry production for the United States.

USGS researchers are pairing field and laboratory studies to gain deeper insights into the role of Lesser Scaup ( Aythya affinis) in the spread and persistence of avian influenza viruses.

Avian influenza, once largely limited to poultry, is now reshaping wildlife health across North America, affecting wild birds, mammals, and even people. This 2025 Year in Review highlights how USGS science is helping track, understand, and respond to this rapidly evolving disease. From large-scale wildlife die-offs to new tools for detecting and monitoring the virus, USGS research supports...

Management of state natural resources is a collaborative effort between state governments, federal agencies, tribal governments, and local stakeholders. USGS Eastern Ecological Science Center (EESC) supports state-led wildlife management with research that clarifies complex issues, enhances scientific quality and communication, broadens solution options, and enables cost-sharing and mutual...

Ongoing global outbreaks demonstrate the capacity of highly pathogenic avian influenza virus (HPAIV) to impact poultry, wild birds, and even human health. USGS research is advancing the understanding of the spatial and temporal interface between wild and domestic bird populations from which these viruses emerge to aid biosecurity planning and outbreak response.

The USGS Eastern Ecological Science Center (EESC) is rooted in a proud tradition of service to the nation—advancing science that informs the conservation and management of fish, wildlife, and habitats across the eastern United States and beyond. Our mission is clear: deliver reliable, partner-driven science that supports natural resource decisions today, while ensuring these resources remain...

The USGS National Wildlife Health Center works with federal, state, Tribal, and other partners to develop practical scientific tools and information to help wildlife managers and other decision-makers prevent, prepare for, and respond to wildlife disease threats. These tools range from direct disease-management interventions—such as vaccines and treatment approaches for invasive species—to...