Environmental Toxicology

About the Research. The Environmental Health Program supports scientists in the Behavioral Toxicology Core Technology Team (CTT) at the Columbia Environmental Research Center. The scientists identify how contaminants alter the behavior of organisms and what implication those changes may have on individuals, populations, and communities.

About the Research The Photomicroscopy and Flow Cytometry Core Technology Team (CTT) as part of the Environmental Health Program works to develop and apply biomarkers to evaluate the potential impacts of environmental contaminants at cellular and molecular levels. Because molecular and biochemical responses of cells are preceded by chemical changes in nuclei, cytoplasm, membranes, and...

About the Research The Functional and Molecular Bioassay Core Technology Team (CTT) as part of the Environmental Health Program utilizes reporter assays, quantitative gene expression analyses, and high-throughput sequencing methods to produce functional endpoints across a broad scope of environmental topics and sample matrices.

Increasing scientific and public awareness of the widespread distribution of per- and poly-fluoroalkyl substances (PFAS) in U.S. drinking-water supplies, aquatic and terrestrial ecosystems, wildlife, and humans has raised many public health and resource management questions that U.S. Geological Survey's (USGS) science can inform. The USGS Environmental Health Program's PFAS Integrated Science Team...

The team is determining the movement and behavior of per- and poly-fluoroalkyl substances (PFAS) from their sources in the environment, as they move through exposure pathways in ecosystems including watersheds and aquifers, their incorporation into food webs, and molecular to population scale effects on fish and wildlife. These studies are accomplished at a variety of spatial scales from regional...

The team studies toxicants and pathogens in water resources from their sources, through watersheds, aquifers, and infrastructure to human and wildlife exposures. That information is used to develop decision tools that protect human and wildlife health.

The Immunomodulation Integrated Science Team focuses on contaminant and pathogen exposures in the environment that might influence the immune systems of wildlife and the connection to their shared environment with humans. In collaboration with public-health officials, the Team also addresses potential human-health risks stemming from similar exposures. If actual risks are identified, this Team...

The Ecologically-Driven Exposure Pathways Integrated Science Team identifies how ecological pathways and physiological processes within a single organism can alter exposure and toxicity of contaminants and pathogens and seek to understand outcomes at different scales from individuals to populations and ecosystems.

To understand if contaminants are associated with white sturgeon population declines, U.S. Geological Survey scientists reviewed the life history, physiology, and behavior of white sturgeon, along with recent toxicological studies and existing trace metal data for locations in the Columbia River. The analysis indicated that the highest concentrations of copper and other metals in the Columbia...

Ecotoxicology and ecological risks of per- and polyfluoroalkyl substances are summarized to highlight critical gaps and uncertainties, and to provide potential approaches to fill those gaps, including the development of targeted monitoring programs and cross-disciplinary approaches.

U.S. Geological Survey scientists and their partners utilize laboratory and field studies and existing information to improve understanding of anticoagulant rodenticide exposure and effects to wild birds.

A National-scale approach is used to examine and analyze per- and polyfluoroalkyl substances (PFAS) prevalence and magnitude in watersheds and aquifers. As an initial step to fill known science gaps in the understanding of human and wildlife exposure, the team will provide a snapshot of PFAS in drinking water paired with bioaccumulation in fish and wildlife near known or suspected sources of...