Food Resources Lifecycle Integrated Science Team
The Team Studies Toxicants and Pathogens
Associated with raising, processing, and manufacturing of animal products
The Team Studies Toxicants and Pathogens
Associated with growing, processing, and manufacturing of plant products
The Team Studies Microbial Contaminants
Associated with Production and Processing of Plant and Animal Products
The team studies the movement of toxicants and pathogens that could originate from the growing, raising, and processing/manufacturing of plant and animal products through the environment where exposure can occur. This information is used to understand if there are adverse effects upon exposure and to develop decision tools to protect health.
Access to an adequate, safe, and sustainable supply of plant and animal products is one of the highest priorities for our society. During the growing and raising of such products requires the management of pests, diseases, and other threats by using a variety of tools such as organic and inorganic nutrients, pesticides, and veterinary pharmaceuticals. These tools often have the added advantage of improving crop yields and increasing livestock weight gain. Best management practices, manufacturer's guidance on safe use, and chemical registration and approval processes administered by the U.S. Environmental Protection Agency, the U.S. Department of Agriculture, and the Food and Drug Administration help farmers minimize health threats. Public concerns, however, regarding potential health threats to fish, wildlife, livestock, and humans posed by use of these tools and management practices are common,and are often based on perceptions rather than scientific information. The Food Resources Lifecycle Science Team designs and implements interdisciplinary research needed to help understand whether these concerns are warranted, and provides objective, unbiased information that decision makers need to address legitimate concerns.
Scientific Focus

The Food Resources Lifecycle Integrated Science Team, part of the Environmental Health Program in the Ecosystems Mission Area, focuses on hazards to the environment and humans associated with complex chemical and biological contaminant mixtures (i.e., antibiotic resistance bacteria/genes, viruses, pesticides, per- and polyfluoroalkyl substances [PFAS], pharmaceuticals, microplastics, etc.) that could originate from the growing, raising, and processing/manufacturing of plant and animal products. The team conducts research in both field and laboratory settings to collectively deliver science to document contaminant sources, fate/transport through the environment to points of exposure, and whether such contaminant exposures pose a health hazard either individually or as complex mixtures.
Research Trajectory
The Team's research consists of multi-year/multi-phased/multidisciplinary efforts conducted to answer questions of national and global significance. These studies build on the knowledge gained from previous research that identified chemical, microbial, and zoonotic environmental contaminants translating to wildlife and human exposures and potential effects. This research often employs an approach where human, plant, animal, and environmental interactions are characterized and combined with a source-to-receptor approach to understand chemical and biological contaminants in the environment from their sources through to aquatic and/or terrestrial organisms.
Priority Research Examples

Infectious avian Influenza (AIV) in environmental waters. AIV maintained in wild bird hosts is episodically spread to domestic poultry, which can lead to economically disastrous outbreaks. The Team is determining if the environment is a medium for maintenance and spread of AIV, which has important implications for the economy, food security, and human/animal health.
Environmental source and distribution of antimicrobial resistance (AMR) and antibiotic genes (ARG). Antimicrobial resistance poses a major threat to human health globally. The Team is determining the role of environmental sources and transfer plays in the development and distribution of AMR and ARG using an approach that acknowledges the connection between the physical environment and the health of humans and wildlife.
Fate and effects of process wastewaters from food, beverage, and feedstock processing plants. Municipal wastewater treatment plants and urban storm water runoff are well documented sources of environmental contaminants. This Team is providing a comparable understanding of chemical and biological contaminants from food-related plant discharges and their potential effects on humans and wildlife.

Environmental exposures and effects of recycled waste reuse on farmland. The demand for treated effluent reuse (as a beneficial source of water) and recycling of solid waste (as a beneficial source of nutrients) is growing and this Team is examining the potential effects and consequences of such reuse and recycling of liquid and solid waste onto farmland.
Effects of agricultural management practices on insect pollinators. Insect pollinators (both domestic and wild) provide a critical role through the maintenance of global plant diversity and pollination of food and fiber crops. Research is underway to better understand the effects of pesticides and other agricultural management practices on insect pollinators.
Environmental exposures to neonicotinoid insecticides. Neonicotinoid pesticides have quickly become the most widely used insecticide globally. Previous research has documented widespread environmental and human exposures and toxicity to selected organisms upon exposure. Consequently, additional research is underway to better understand human and wildlife environmental exposures to neonicotinoid pesticides and effects on humans and wildlife.

Related science products listed below.
Organic Contaminants in Reuse Waters and Transport Following Land Application
Pesticides Detected in Bees, Flowers, Soil, and Air within Pollinator-Attractive Row-Crop Border Plantings
Study Provides a Data Resource for Per- and Polyfluoroalkyl Substances in Streams Within Iowa Agricultural Watersheds
Science to Understand Low-Level Exposures to Neonicotinoid Pesticides, their Metabolites, and Chlorinated Byproducts in Drinking Water
Effect of Chronic Neonicotinoid Insecticide Exposure upon Monarch Development
Scientists Examined Native Pollinator Exposure Risk to Neonicotinoids in Native Prairie Strips
Native Bees are Exposed to Neonicotinoids and Other Pesticides
Neonicotinoid Insecticides Documented in Midwestern U.S. Streams
The following are the data releases from this science team’s research activities.
Solutions and extended results for laboratory tests used in the development of a large volume concentration method to recover infectious avian influenza virus from the aquatic environment, 2022
Zebrafish length and pericardial area data observed through high content screening in experimental 384 well plates exposed to different pesticides for 72 hour
Pesticide, organic-contaminant, and wastewater-indicator results for passive samplers deployed in surface water and groundwater in Hawaiʻi, 2015–19
Concentrations of 6PPD and 6PPD-Quinone in a United States reconnaissance of stormwater, surface water, and groundwater, 2018-24
Water chemistry data observed in experimental laboratory mesocosms exposed to different nitrapyrin and nitrogen amendments in the presence or absence of a nitrifier enriched microbial (NEM) community
Pesticide residues in monarch butterflies collected from Pacific Grove, California, USA in January 2024
Histopathology of American Kestrels (Falco sparverius) Exposed to Two Brodifacoum Isomer Formulations with Differing Elimination Half-Lives
Brodifacoum isomer formulation study
Plant and insect pollinator diversity data from Conservation Reserve Program fields across an agricultural gradient in eastern Iowa
Images and Identifications of Wild Bees Collected in Eastern Iowa, 2019
Physiological and molecular endpoints observed in juvenile largemouth bass in response to an estrogen (17α-ethinylestradiol) and subsequently a bacterial challenge (Edwardsiella piscicida) exposure under laboratory conditions.
Water quality and atmospheric carbon dioxide data for field application of carbon dioxide during summer 2018 as a behavioral control method for invasive red swamp crayfish (Procambarus clarkii) in southeastern Michigan water retention ponds.
Below are publications associated with this science team.
Development of a large-volume concentration method to recover infectious avian influenza virus from the aquatic environment
Pesticides in surface water downstream of and near agricultural and developed land in Hawai‘i, 2015–19
U.S. Geological Survey Mississippi River Science Forum—Summary of data and science needs and next steps
Tire-derived contaminants 6PPD and 6PPD-Q: Analysis, sample handling, and reconnaissance of United States stream exposures
Low-level dietary clothianidin exposure preferentially causes prepupal mortality of monarch butterflies (Danaus plexippus)
Integrated science for the study of microplastics in the environment—A strategic science vision for the U.S. Geological Survey
Comparing modern identification methods for wild bees: Metabarcoding and image-based morphological taxonomic assignment
Nitrate exposure from drinking water and dietary sources among Iowa farmers using private wells
Pesticides in small volume plasma samples: Method development and application to smallmouth bass (Micropterus dolomieu) from the Chesapeake Bay watershed, USA
Water, water everywhere, but every drop unique: Emerging challenges in the science to understand the role of contaminants in management of drinking water supplies
Adult mosquito and butterfly exposure to permethrin and relative risk following ULV sprays from a truck-mounted sprayer
Evaluation of anticoagulant rodenticide sensitivity by examining in vivo and in vitro responses in avian species, focusing on raptors
The team studies the movement of toxicants and pathogens that could originate from the growing, raising, and processing/manufacturing of plant and animal products through the environment where exposure can occur. This information is used to understand if there are adverse effects upon exposure and to develop decision tools to protect health.
Access to an adequate, safe, and sustainable supply of plant and animal products is one of the highest priorities for our society. During the growing and raising of such products requires the management of pests, diseases, and other threats by using a variety of tools such as organic and inorganic nutrients, pesticides, and veterinary pharmaceuticals. These tools often have the added advantage of improving crop yields and increasing livestock weight gain. Best management practices, manufacturer's guidance on safe use, and chemical registration and approval processes administered by the U.S. Environmental Protection Agency, the U.S. Department of Agriculture, and the Food and Drug Administration help farmers minimize health threats. Public concerns, however, regarding potential health threats to fish, wildlife, livestock, and humans posed by use of these tools and management practices are common,and are often based on perceptions rather than scientific information. The Food Resources Lifecycle Science Team designs and implements interdisciplinary research needed to help understand whether these concerns are warranted, and provides objective, unbiased information that decision makers need to address legitimate concerns.
Scientific Focus

The Food Resources Lifecycle Integrated Science Team, part of the Environmental Health Program in the Ecosystems Mission Area, focuses on hazards to the environment and humans associated with complex chemical and biological contaminant mixtures (i.e., antibiotic resistance bacteria/genes, viruses, pesticides, per- and polyfluoroalkyl substances [PFAS], pharmaceuticals, microplastics, etc.) that could originate from the growing, raising, and processing/manufacturing of plant and animal products. The team conducts research in both field and laboratory settings to collectively deliver science to document contaminant sources, fate/transport through the environment to points of exposure, and whether such contaminant exposures pose a health hazard either individually or as complex mixtures.
Research Trajectory
The Team's research consists of multi-year/multi-phased/multidisciplinary efforts conducted to answer questions of national and global significance. These studies build on the knowledge gained from previous research that identified chemical, microbial, and zoonotic environmental contaminants translating to wildlife and human exposures and potential effects. This research often employs an approach where human, plant, animal, and environmental interactions are characterized and combined with a source-to-receptor approach to understand chemical and biological contaminants in the environment from their sources through to aquatic and/or terrestrial organisms.
Priority Research Examples

Infectious avian Influenza (AIV) in environmental waters. AIV maintained in wild bird hosts is episodically spread to domestic poultry, which can lead to economically disastrous outbreaks. The Team is determining if the environment is a medium for maintenance and spread of AIV, which has important implications for the economy, food security, and human/animal health.
Environmental source and distribution of antimicrobial resistance (AMR) and antibiotic genes (ARG). Antimicrobial resistance poses a major threat to human health globally. The Team is determining the role of environmental sources and transfer plays in the development and distribution of AMR and ARG using an approach that acknowledges the connection between the physical environment and the health of humans and wildlife.
Fate and effects of process wastewaters from food, beverage, and feedstock processing plants. Municipal wastewater treatment plants and urban storm water runoff are well documented sources of environmental contaminants. This Team is providing a comparable understanding of chemical and biological contaminants from food-related plant discharges and their potential effects on humans and wildlife.

Environmental exposures and effects of recycled waste reuse on farmland. The demand for treated effluent reuse (as a beneficial source of water) and recycling of solid waste (as a beneficial source of nutrients) is growing and this Team is examining the potential effects and consequences of such reuse and recycling of liquid and solid waste onto farmland.
Effects of agricultural management practices on insect pollinators. Insect pollinators (both domestic and wild) provide a critical role through the maintenance of global plant diversity and pollination of food and fiber crops. Research is underway to better understand the effects of pesticides and other agricultural management practices on insect pollinators.
Environmental exposures to neonicotinoid insecticides. Neonicotinoid pesticides have quickly become the most widely used insecticide globally. Previous research has documented widespread environmental and human exposures and toxicity to selected organisms upon exposure. Consequently, additional research is underway to better understand human and wildlife environmental exposures to neonicotinoid pesticides and effects on humans and wildlife.

Related science products listed below.
Organic Contaminants in Reuse Waters and Transport Following Land Application
Pesticides Detected in Bees, Flowers, Soil, and Air within Pollinator-Attractive Row-Crop Border Plantings
Study Provides a Data Resource for Per- and Polyfluoroalkyl Substances in Streams Within Iowa Agricultural Watersheds
Science to Understand Low-Level Exposures to Neonicotinoid Pesticides, their Metabolites, and Chlorinated Byproducts in Drinking Water
Effect of Chronic Neonicotinoid Insecticide Exposure upon Monarch Development
Scientists Examined Native Pollinator Exposure Risk to Neonicotinoids in Native Prairie Strips
Native Bees are Exposed to Neonicotinoids and Other Pesticides
Neonicotinoid Insecticides Documented in Midwestern U.S. Streams
The following are the data releases from this science team’s research activities.
Solutions and extended results for laboratory tests used in the development of a large volume concentration method to recover infectious avian influenza virus from the aquatic environment, 2022
Zebrafish length and pericardial area data observed through high content screening in experimental 384 well plates exposed to different pesticides for 72 hour
Pesticide, organic-contaminant, and wastewater-indicator results for passive samplers deployed in surface water and groundwater in Hawaiʻi, 2015–19
Concentrations of 6PPD and 6PPD-Quinone in a United States reconnaissance of stormwater, surface water, and groundwater, 2018-24
Water chemistry data observed in experimental laboratory mesocosms exposed to different nitrapyrin and nitrogen amendments in the presence or absence of a nitrifier enriched microbial (NEM) community
Pesticide residues in monarch butterflies collected from Pacific Grove, California, USA in January 2024
Histopathology of American Kestrels (Falco sparverius) Exposed to Two Brodifacoum Isomer Formulations with Differing Elimination Half-Lives
Brodifacoum isomer formulation study
Plant and insect pollinator diversity data from Conservation Reserve Program fields across an agricultural gradient in eastern Iowa
Images and Identifications of Wild Bees Collected in Eastern Iowa, 2019
Physiological and molecular endpoints observed in juvenile largemouth bass in response to an estrogen (17α-ethinylestradiol) and subsequently a bacterial challenge (Edwardsiella piscicida) exposure under laboratory conditions.
Water quality and atmospheric carbon dioxide data for field application of carbon dioxide during summer 2018 as a behavioral control method for invasive red swamp crayfish (Procambarus clarkii) in southeastern Michigan water retention ponds.
Below are publications associated with this science team.